Dihydroergotamine Injection

157 interactions 472 cited references

Also sold as: DHE-45® Injection Migranal Trudhesa

About Dihydroergotamine Injection

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light) and cluster headaches (severe headaches usually on one side of the head or around one eye). Dihydroergotamine is in a class of medications called ergot alkaloid… Read the full Dihydroergotamine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Erythromycin Zolmitriptan Fosamprenavir Itraconazole Indinavir Frovatriptan

62 Contraindicated 79 Major 16 Moderate

All (157) Contraindicated (62) Major (79) Moderate (16)

Contraindicated

Dihydroergotamine Injection Adagrasib Krazati Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Almotriptan Increased risk of coronary artery vasospasm Details Dihydroergotamine Injection Amprenavir Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, peripheral vasospasm, and peripheral isc... Details Dihydroergotamine Injection Atazanavir Reyataz An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Dihydroergotamine Injection Boceprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Bromocriptine Cycloset An increased risk of ergotism Details Dihydroergotamine Injection Ceritinib Zykadia Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Clarithromycin Biaxin Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Injection Cobicistat Tybost An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Dihydroergotamine Injection Darunavir An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Dihydroergotamine Injection Delavirdine Rescriptor® Increased dihydroergotamine exposure and an increased risk of ergot toxicity (vasospastic ischemia) Details Dihydroergotamine Injection Dobutamine Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Dopamine Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Eletriptan Relpax Increased risk of prolonged vasospastic reactions Details Dihydroergotamine Injection Ensitrelvir Increased ergot derivatives exposure; an increased risk of ergot derivatives-related toxicity Details Dihydroergotamine Injection Ephedrine Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Epinephrine Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Ergoloid Mesylates Alkergot® An increased risk of ergotism Details Dihydroergotamine Injection Ergonovine An increased risk of ergotism Details Dihydroergotamine Injection Ergotamine Ergomar An increased risk of ergotism Details Dihydroergotamine Injection Erythromycin Erythrocin Stearate Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Injection Fosamprenavir Lexiva Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, peripheral vasospasm, and peripheral isc... Details Dihydroergotamine Injection Frovatriptan Frova Prolonged vasospastic reactions Details Dihydroergotamine Injection Idelalisib Zydelig Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity Details Dihydroergotamine Injection Indinavir Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Itraconazole Sporanox An increased risk of ergotism (vasospasm leading to cerebral ischemia and/or ischemia of the extremities) Details Dihydroergotamine Injection Ketoconazole Extina Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Letermovir Prevymis Increased ergot alkaloids exposure and an increased risk of ergotism Details Dihydroergotamine Injection Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Dihydroergotamine Injection Lisuride An increased risk of ergotism Details Dihydroergotamine Injection Lonafarnib Zokinvy Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Lopinavir An increased risk of dihydroergotamine toxicity including nausea, vomiting, and vasospastic ischemia Details Dihydroergotamine Injection Metergoline An increased risk of ergotism Details Dihydroergotamine Injection Methylergonovine Methergine An increased risk of ergotism Details Dihydroergotamine Injection Methysergide An increased risk of ergotism Details Dihydroergotamine Injection Mifepristone Korlym Increased dihydroergotamine exposure and risk of adverse events Details Dihydroergotamine Injection Naratriptan Prolonged vasospastic reactions Details Dihydroergotamine Injection Nefazodone Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Nelfinavir Viracept Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Nicergoline An increased risk of ergotism Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.