Dihydroergotamine Injection

157 interactions 472 cited references
Also sold as: DHE-45® Injection Migranal Trudhesa
About Dihydroergotamine Injection

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light) and cluster headaches (severe headaches usually on one side of the head or around one eye). Dihydroergotamine is in a class of medications called ergot alkaloid… Read the full Dihydroergotamine Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Moderate

Dihydroergotamine Injection Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Injection Citalopram Celexa An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Injection Escitalopram Lexapro An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Injection Infliximab Avsola Decreased dihydroergotamine plasma concentrations Details Dihydroergotamine Injection Kratom Increased CYP3A substrate exposure Details Dihydroergotamine Injection Lapatinib Tykerb Increased exposure of dihydroergotamine Details Dihydroergotamine Injection Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Injection Metreleptin Altered exposure to dihydroergotamine Details Dihydroergotamine Injection Metronidazole Flagyl Increased plasma concentrations of ergot derivatives and increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Nitroglycerin Gonitro Dihydroergotamine toxicity (peripheral ischemia, paresthesias, nausea, vomiting) Details Dihydroergotamine Injection Paroxetine Paxil An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Injection Rilonacept Altered dihydroergotamine plasma concentrations Details Dihydroergotamine Injection Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Dihydroergotamine Injection Sertraline An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Injection Vilazodone Viibryd An increased risk of weakness, hyperreflexia and incoordination Details Dihydroergotamine Injection Vortioxetine Trintellix An increased risk of weakness, hyperreflexia and incoordination Details

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