Dihydroergotamine Injection

157 interactions 472 cited references

Also sold as: DHE-45® Injection Migranal Trudhesa

About Dihydroergotamine Injection

Dihydroergotamine is used to treat migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light) and cluster headaches (severe headaches usually on one side of the head or around one eye). Dihydroergotamine is in a class of medications called ergot alkaloid… Read the full Dihydroergotamine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Erythromycin Zolmitriptan Fosamprenavir Itraconazole Indinavir Frovatriptan

62 Contraindicated 79 Major 16 Moderate

All (157) Contraindicated (62) Major (79) Moderate (16)

Contraindicated

Dihydroergotamine Injection Nirmatrelvir Increased risk of ergot toxicity Details Dihydroergotamine Injection Norepinephrine Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Paritaprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Phenylephrine Biorphen Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Phenylpropanolamine Extreme elevation of blood pressure Details Dihydroergotamine Injection Posaconazole Noxafil Increased dihydroergotamine exposure and an increased risk of ergotism Details Dihydroergotamine Injection Propylhexedrine Extreme elevation of blood pressure Details Dihydroergotamine Injection Pseudoephedrine Afrinol® Extreme elevation of blood pressure Details Dihydroergotamine Injection Ribociclib Kisqali Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Ritonavir Norvir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Rizatriptan Prolonged vasospastic reactions Details Dihydroergotamine Injection Saquinavir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Saralasin Extreme elevation of blood pressure Details Dihydroergotamine Injection Sumatriptan Imitrex Increased risk of coronary artery vasospasm Details Dihydroergotamine Injection Telaprevir Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Telithromycin An increased risk of acute ergot toxicity Details Dihydroergotamine Injection Tipranavir Aptivus An increased risk of dihydroergotamine toxicity including nausea, vomiting, and vasospastic ischemia Details Dihydroergotamine Injection Troleandomycin Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Injection Tucatinib Tukysa Increased dihydroergotamine exposure and an increased risk of dihydroergotamine-related adverse effects Details Dihydroergotamine Injection Vasopressin Vasostrict Increased risk of elevation of blood pressure Details Dihydroergotamine Injection Voriconazole Vfend Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Zolmitriptan Zomig Prolonged vasospastic reactions Details

Major

Dihydroergotamine Injection Abametapir Increased exposure of CYP3A4 substrate Details Dihydroergotamine Injection Alefacept Decreased dihydroergotamine plasma concentrations Details Dihydroergotamine Injection Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Dihydroergotamine Injection Aprepitant Aponvie Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Dihydroergotamine Injection Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Dihydroergotamine Injection Azithromycin AzaSite An increased risk of acute ergot toxicity (ergotism) Details Dihydroergotamine Injection Belzutifan Welireg Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Dihydroergotamine Injection Berotralstat Orladeyo Increased CYP3A4 substrate exposure and an increased CYP3A4 substrate-related adverse reactions Details Dihydroergotamine Injection Carbamazepine Carbatrol Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Dihydroergotamine Injection Ciprofloxacin Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Clofazimine Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Clotrimazole Aardora Anti-Fungal Maximum Strength Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Dihydroergotamine Injection Conivaptan Vaprisol Increased CYP3A substrate exposure Details Dihydroergotamine Injection Crizotinib Xalkori Increased dihydroergotamine exposure Details Dihydroergotamine Injection Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Dihydroergotamine Injection Daridorexant Increased CYP3A4 substrate with NTI exposure Details Dihydroergotamine Injection Dexfenfluramine Serotonin syndrome (confusion, mental status changes, diaphoresis, tremor, myoclonus, shivering, hyperreflexia, hypertension) Details

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