Dihydroergotamine Injection and Posaconazole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Posaconazole
Dihydroergotamine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dihydroergotamine exposure and an increased risk of ergotism
Interaction Deep Dive
Coadministration of posaconazole and dihydroergotamine (ergot alkaloid) is contraindicated as it may result in increased dihydroergotamine exposure and may lead to ergotism12.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of dihydroergotamine
Common questions
Can I take Dihydroergotamine Injection and Posaconazole together?
Increased dihydroergotamine exposure and an increased risk of ergotism Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dihydroergotamine Injection and Posaconazole interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Dihydroergotamine Injection or Posaconazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: NOXAFIL(R) PowderMix delayed-release oral suspension, posaconazole delayed-release oral suspension. Merck Sharp & Dohme LLC (per FDA), Rahway, NJ, 2024. DailyMed
- Product Information: Posaconazole oral delayed-release tablets, posaconazole oral delayed-release tablets. SpecGx LLC (per DailyMed), Webster Groves, MO, 2024. DailyMed
Keep reading about Posaconazole
Keep reading about Dihydroergotamine Injection
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