Alogliptin and Tenofovir Alafenamide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Alogliptin
Tenofovir Alafenamide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects
Interaction Deep Dive
Coadministration of tenofovir alafenamide (P-gp substrate) or tenofovir alafenamide-containing combination products with P-gp inhibitors may increase tenofovir alafenamide exposure which may result in increased risk of tenofovir alafenamide-related adverse reactions123.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport of tenofovir alafenamide
Common questions
Can I take Alogliptin and Tenofovir Alafenamide together?
Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Alogliptin and Tenofovir Alafenamide interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Alogliptin or Tenofovir Alafenamide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: SYMTUZA(R) oral tablets, darunavir, cobicistat, emtricitabine, tenofovir alafenamide oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2023. DailyMed
- Product Information: BIKTARVY(R) oral tablets, bictegravir, emtricitabine, tenofovir alafenamide oral tablets. Gilead Sciences Inc (per FDA), Foster City, CA, 2024. DailyMed
- Product Information: DESCOVY(R) oral tablets, emtricitabine tenofovir alafenamide oral tablets. Gilead Sciences Inc (per FDA), Foster City, CA, 2025. DailyMed
Keep reading about Alogliptin
Keep reading about Tenofovir Alafenamide
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