Alogliptin

129 interactions 209 cited references

Also sold as: Nesina Nesina®

About Alogliptin

Alogliptin is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Alogliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by incre… Read the full Alogliptin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Insulin Degludec (Rdna Origin) Injection Abiraterone Abiraterone Acetate Abiraterone Acetate, Micronized Ofloxacin Otic

1 Contraindicated 81 Major 47 Moderate

All (129) Contraindicated (1) Major (81) Moderate (47)

Major

Alogliptin Relugolix Orgovyx Increased relugolix exposure Details Alogliptin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Alogliptin Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Alogliptin Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Alogliptin Chloroquine Aralen® Hypoglycemia Details Alogliptin Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Clomipramine Anafranil Increased clomiPRAMINE exposure Details Alogliptin Cyclosporine Atopica Increased cycloSPORINE exposure Details Alogliptin Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Alogliptin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Dextroamphetamine Dexedrine Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details Alogliptin Digoxin Cardoxin® Increased digoxin exposure Details Alogliptin Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Alogliptin Doxorubicin Hydrochloride Liposome Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Alogliptin Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Ensartinib Increased ensartinib exposure Details Alogliptin Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Alogliptin Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Alogliptin Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Alogliptin Insulin Afrezza An increased risk of hypoglycemia Details Alogliptin Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Alogliptin Insulin Bovine An increased risk of hypoglycemia Details Alogliptin Insulin Degludec Tresiba An increased risk of hypoglycemia Details Alogliptin Insulin Detemir Levemir An increased risk of hypoglycemia Details Alogliptin Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Alogliptin Insulin Glulisine Apidra An increased risk of hypoglycemia Details Alogliptin Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Alogliptin Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Alogliptin Lanreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Alogliptin Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Alogliptin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Alogliptin Lisdexamfetamine Arynta Increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an increased risk of serotonin syndrom... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.