Amlodipine

195 interactions 821 cited references
Also sold as: Amvaz® Katerzia Katerzia® Norliqva Norvasc Norvasc® Sdamlo
About Amlodipine

Amlodipine is a calcium channel blocker used to treat high blood pressure, chest pain, and narrowing of heart blood vessels. Read the full Amlodipine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amlodipine Dipyrone Reduced amLODIPine exposure Details Amlodipine Domperidone Increased domperidone exposure and an increased risk of QT prolongation Details Amlodipine Dronedarone Multaq Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Duvelisib Copiktra Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Echinacea Reduced amLODIPine exposure Details Amlodipine Elafibranor Iqirvo Reduced amLODIPine exposure Details Amlodipine Elagolix Orilissa Reduced amLODIPine exposure Details Amlodipine Enasidenib Idhifa Reduced amLODIPine exposure Details Amlodipine Encorafenib Braftovi Reduced amLODIPine exposure Details Amlodipine Enzalutamide Xtandi Reduced amLODIPine exposure Details Amlodipine Epirubicin Ellence Increased risk of heart failure Details Amlodipine Erythromycin Erythrocin Stearate Increased amLODIPine exposure, an increased amLODIPine-related adverse reactions and an increased risk of hypotension Details Amlodipine Eslicarbazepine Acetate Aptiom Reduced amLODIPine exposure Details Amlodipine Etravirine Intelence Reduced amLODIPine exposure Details Amlodipine Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Amlodipine Fexinidazole An increased CYP3A4 substrate exposure Details Amlodipine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Amlodipine Fluconazole Diflucan Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Fosamprenavir Lexiva Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Fosnetupitant Increased exposure of CYP3A4 substrate Details Amlodipine Fosphenytoin Cerebyx Reduced amLODIPine exposure Details Amlodipine Garlic Reduced amLODIPine exposure Details Amlodipine Ginkgo Reduced amLODIPine exposure Details Amlodipine Ginseng Reduced amLODIPine exposure Details Amlodipine Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Amlodipine Idelalisib Zydelig Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Imatinib Gleevec Increased amLODIPine exposure, an increased risk of hypotension and edema and increased risk of imatinib toxicity Details Amlodipine Isavuconazole Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Isavuconazonium Cresemba Increased amLODIPine exposure, an increased risk of hypotension and edema and reduced amLODIPine exposure Details Amlodipine Itraconazole Sporanox Increased amlodipine exposure and an increased risk of congestive heart failure Details Amlodipine Ivosidenib Tibsovo Reduced amLODIPine exposure Details Amlodipine Ketoconazole Extina Increased calcium channel blockers that are CYP3A4 substrates exposure and an increased risk of calcium channel blockers that are... Details Amlodipine Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Amlodipine Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Amlodipine Lefamulin Xenleta Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Amlodipine Lenacapavir Sunlenca Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Lesinurad Reduced amLODIPine exposure Details Amlodipine Letermovir Prevymis Increased amLODIPine exposure and an increased risk of hypotension and edema Details Amlodipine Lomitapide Increased lomitapide exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.