Amphetamine

34 interactions 6 explained in plain English

Also sold as: Dexedrine ProCentra Xelstrym Zenzedi

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Acetaminophen And Codeine Palonosetron Injection Dexlansoprazole Esomeprazole Methylphenidate

1 Contraindicated 31 Major 2 Moderate

All (34) Contraindicated (1) Major (31) Moderate (2)

Major

Amphetamine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Amphetamine Omeprazole Gastrobim Explained Increased exposure to amphetamine Details Amphetamine Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Amphetamine Sertraline Explained Increased amphetamine exposure and an increased risk of serotonin syndrome Details Amphetamine Albuterol Oral Inhalation Accuneb® Explained Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Amphetamine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Amphetamine Acetazolamide Diamox® Sequels® Increased exposure to amphetamine Details Amphetamine Abiraterone Abirtega Increased amphetamine exposure and increased risk of serotonin syndrome Details Amphetamine Butorphanol Injection Butorphic An increased risk of serotonin syndrome Details Amphetamine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome Details Amphetamine Clonidine Transdermal Patch Catapres Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Amphetamine Dacomitinib Vizimpro Increased amphetamine exposure and increased risk of serotonin syndrome Details Amphetamine Dexlansoprazole Dexilant Increased exposure to amphetamine Details Amphetamine Dolasetron Anzemet An increased risk of serotonin syndrome Details Amphetamine Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Amphetamine Droxidopa Northera Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Amphetamine Esomeprazole Nexium Increased exposure to amphetamine Details Amphetamine Esomeprazole Injection Nexium Increased exposure to amphetamine Details Amphetamine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Amphetamine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Amphetamine Granisetron Injection Granisol An increased risk of serotonin syndrome Details Amphetamine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Amphetamine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Amphetamine Lansoprazole Prevacid Increased exposure to amphetamine Details Amphetamine Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Amphetamine Methylphenidate Adhansia XR® Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Amphetamine Methylphenidate Transdermal Patch Daytrana Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Amphetamine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Amphetamine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome Details Amphetamine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Amphetamine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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