Amphotericin B and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Injection
Amphotericin B
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of renal dysfunction
Interaction Deep Dive
Use caution when using cycloSPORINE with other drugs which are known to impair renal function like amphotericin B. During the concomitant use of a drug that may exhibit additive or synergistic renal impairment with cycloSPORINE, close monitoring of renal function (serum creatinine) should be performed. If a significant impairment of renal function occurs, reduce the dosage of the cycloSPORINE and/or coadministered drug or consider an alternative treatment12. In bone marrow transplant patients, a high incidence of nephrotoxicity was noted in those patients receiving concurrent cycloSPORINE and amphotericin B. Serum creatinine doubled in 80% of patients on concurrent medications within 5 days vs 38% of patients on cycloSPORINE alone 3. In another study also involving bone marrow transplant recipients, significant renal toxicity was observed in 83% of subjects who received amphotericin B and cycloSPORINE concurrently compared with 10% of patients who received cycloSPORINE monotherapy 4.
Why it happens (mechanism)
Additive or synergistic nephrotoxicity
Literature reports
1 report — tap to read
a) In bone marrow transplant patients, a high incidence of nephrotoxicity was noted in those patients receiving concurrent cycloSPORINE and amphotericin B. Serum creatinine doubled in 80% of patients on concurrent medications within 5 days vs 38% of patients on cycloSPORINE alone 3. In another study also involving bone marrow transplant recipients, significant renal toxicity was observed in 83% of subjects who received amphotericin B and cycloSPORINE concurrently compared with 10% of patients who received cycloSPORINE monotherapy 4.
Common questions
Can I take Amphotericin B and Cyclosporine Injection together?
An increased risk of renal dysfunction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amphotericin B and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Amphotericin B or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: NEORAL(R) oral soft gelatin capsules oral solution, cyclosporine modified oral soft gelatin capsules oral solution. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
- Product Information: SANDIMMUNE(R) oral capsules, oral solution, intravenous injection, cyclosporine oral capsules, oral solution, intravenous injection. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2023. DailyMed
- Kennedy MS, Deeg HJ, Siegel M, et al: Acute renal toxicity with combined use of amphotericin B and cyclosporine after marrow transplantation. Transplantation 1983; 35:211-215. PubMed
- Campana C, Regazzi MB, Buggia I, et al: Clinically significant drug interactions with cyclosporin. Clin Pharmacokinet 1996; 30:141-179. DOI
Keep reading about Cyclosporine Injection
Keep reading about Amphotericin B
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