Amphotericin B

Name: Amphotericin B Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Arsenic Trioxide Arsenic Trioxide Injection Aspirin Aspirin Rectal Cyclosporine Injection Cyclosporine Ophthalmic

8 Major 1 Moderate

All (9) Major (8) Moderate (1)

Major

Amphotericin B Arsenic Trioxide Trisenox Increased risk of QT prolongation Details Amphotericin B Arsenic Trioxide Injection Trisenox Increased risk of QT prolongation Details Amphotericin B Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Amphotericin B Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Amphotericin B Cyclosporine Injection Atopica An increased risk of renal dysfunction Details Amphotericin B Cyclosporine Ophthalmic Cequa An increased risk of renal dysfunction Details Amphotericin B Foscarnet Injection Foscavir Nephrotoxicity Details Amphotericin B Hydroxychloroquine Plaquenil An increased risk of seizures Details

Moderate

Amphotericin B Digoxin Cardoxin® Hypokalemia and digitalis toxicity (nausea, vomiting, visual disturbances, cardiac arrhythmias) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.