Ampicillin Injection

57 interactions 1 explained in plain English 590 cited references
Also sold as: Omnipen-N® Penbritin-S® Polycillin-N® Polyflex Totacillin-N®
About Ampicillin Injection

Ampicillin injection is used to treat certain infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and lung, blood, heart, urinary tract, and gastrointestinal tract infections. Ampicillin injection is in a class of medications called penicillins.… Read the full Ampicillin Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Chlortetracycline Cholera Vaccine, Live Clomipramine Demeclocycline
36 Major 10 Moderate 11 Minor
All (57) Major (36) Moderate (10) Minor (11)

Major

Ampicillin Injection Amifampridine Increased risk of seizures Details Ampicillin Injection Bupropion Aplenzin Increased risk of seizures Details Ampicillin Injection Chlortetracycline Decreased antibacterial effectiveness Details Ampicillin Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Ampicillin Injection Clomipramine Anafranil Increased risk of seizures Details Ampicillin Injection Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Ampicillin Injection Desogestrel Decreased contraceptive effectiveness Details Ampicillin Injection Dienogest Decreased contraceptive effectiveness Details Ampicillin Injection Donepezil Adlarity Reduced seizure threshold Details Ampicillin Injection Doxycycline Acticlate Decreased antibacterial effectiveness Details Ampicillin Injection Drospirenone Decreased contraceptive effectiveness Details Ampicillin Injection Eravacycline Xerava Decreased antibacterial effectiveness Details Ampicillin Injection Estradiol Delestrogen Decreased contraceptive effectiveness Details Ampicillin Injection Ethinyl Estradiol Decreased contraceptive effectiveness Details Ampicillin Injection Ethynodiol Decreased contraceptive effectiveness Details Ampicillin Injection Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Ampicillin Injection Gestodene Decreased contraceptive effectiveness Details Ampicillin Injection Hydroxychloroquine Plaquenil Reduced hydroxychloroquine bioavailability and an increased risk of seizures Details Ampicillin Injection Levonorgestrel After banger Decreased contraceptive effectiveness Details Ampicillin Injection Lymecycline Decreased antibacterial effectiveness Details Ampicillin Injection Meclocycline Decreased antibacterial effectiveness Details Ampicillin Injection Mestranol Decreased contraceptive effectiveness Details Ampicillin Injection Methacycline Decreased antibacterial effectiveness Details Ampicillin Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ampicillin Injection Minocycline Amzeeq Decreased antibacterial effectiveness Details Ampicillin Injection Nomegestrol Decreased contraceptive effectiveness Details Ampicillin Injection Norethindrone Aygestin Decreased contraceptive effectiveness Details Ampicillin Injection Norgestimate Decreased contraceptive effectiveness Details Ampicillin Injection Norgestrel Decreased contraceptive effectiveness Details Ampicillin Injection Oxytetracycline Decreased antibacterial effectiveness Details Ampicillin Injection Rolitetracycline Decreased antibacterial effectiveness Details Ampicillin Injection Sarecycline Seysara Decreased antibacterial effectiveness Details Ampicillin Injection Tetracycline Achromycin V® Decreased antibacterial effectiveness Details Ampicillin Injection Tigecycline Tygacil Decreased antibacterial effectiveness Details Ampicillin Injection Tramadol ConZip An increased risk of seizure Details Ampicillin Injection Warfarin Coumadin An increased risk of bleeding Details

Moderate

Ampicillin Injection Chloroquine Aralen® Decreased chloroquine bioavailability Details Ampicillin Injection Dexlansoprazole Dexilant Reduced ampicillin bioavailability Details Ampicillin Injection Entacapone Comtan An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Ampicillin Injection Khat Reduced effectiveness of ampicillin Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.