Anakinra and Infliximab: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Anakinra
Infliximab
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of serious infections
Interaction Deep Dive
The use of anakinra in combination with TNF blocking agents, including infliximab or infliximab biosimilar products are, is not recommended123. The concomitant use of anakinra and another TNF blocking agent, etanercept, was associated with an increased risk of serious infection and neutropenia, and provided no additional benefit 4.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) The concomitant use of anakinra and another TNF blocking agent, etanercept, was associated with an increased risk of serious infection and neutropenia, and provided no additional benefit 4.
Common questions
Can I take Anakinra and Infliximab together?
An increased risk of serious infections Always confirm with your pharmacist or prescriber before making any change.
How serious is the Anakinra and Infliximab interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Anakinra or Infliximab need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: RENFLEXIS intravenous injection powder for solution, infliximab-abda intravenous injection powder for solution. Organon & Co. (per FDA), Jersey City, NJ, 2023. DailyMed
- Product Information: INFLECTRA intravenous injection, infliximab-dyyb intravenous injection. Hospira (per FDA), Lake Forest, IL, 2016. DailyMed
- Product Information: REMICADE(R) intravenous injection lyophilized concentrate, infliximab intravenous injection lyophilized concentrate. Janssen Biotech, Inc. (per FDA), Horsham, PA, 2015. DailyMed
- Product Information: Kineret(R), anakinra injection. Amgen, Inc. Thousand Oaks, CA, 2004. DailyMed
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