Anidulafungin and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Injection
Anidulafungin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased anidulafungin exposure
Interaction Deep Dive
The steady state AUC of anidulafungin was increased 22% when cycloSPORINE was added to the drug regimen. In vitro data indicate that anidulafungin has no effect on the metabolism of cycloSPORINE. No dosage adjustment is necessary for either drug1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) Concomitant of anidulafungin and cycloSPORINE resulted in a slight increase in anidulafungin AUC. Twelve healthy adults received a 200 mg loading dose of anidulafungin followed by 100 mg/day maintenance dose on days 1 to 8. CycloSPORINE 1.25 mg/kg was given orally twice a day on days 5 to 8. Steady state Cmax of anidulafungin was not significantly altered, while the steady state AUC increased by 22%. Anidulafungin had no effect on the metabolism of cycloSPORINE in a separate in vitro study 1.
Common questions
Can I take Anidulafungin and Cyclosporine Injection together?
Increased anidulafungin exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Anidulafungin and Cyclosporine Injection interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Anidulafungin or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: ERAXIS(TM) IV injection, anidulafungin iv injection. Pfizer Inc. New York, NY, 2006.
Keep reading about Cyclosporine Injection
Keep reading about Anidulafungin
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