Apremilast

Name: Apremilast Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

18 interactions 44 cited references

Also sold as: Otezla Otezla®

About Apremilast

Apremilast is used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). It is also used to treat moderate to severe plaque psoriasis (skin disease in which red, scaly patches form on some areas of the body) in people who may benefit from medications or phototherapy (a t… Read the full Apremilast drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Rifampin Mitotane Omaveloxolone Phenytoin Rifapentine

1 Contraindicated 15 Major 2 Moderate

All (18) Contraindicated (1) Major (15) Moderate (2)

Moderate

Apremilast Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Apremilast Kratom Increased CYP3A substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.