Aprobarbital

Name: Aprobarbital Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Doxorubicin Doxycycline Injection Midazolam Nasal Spray Midazolam Injection

5 Major 4 Moderate

All (9) Major (5) Moderate (4)

Major

Aprobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Aprobarbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Aprobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Aprobarbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Aprobarbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details

Moderate

Aprobarbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Aprobarbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Aprobarbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Aprobarbital Ospemifene Osphena Decreased ospemifene exposure and efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.