Asciminib

154 interactions 4 explained in plain English 277 cited references

Also sold as: Scemblix Scemblix®

About Asciminib

Asciminib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) as a first treatment and in people who can no longer benefit from other leukemia medications. Asciminib is in a class of medications called kinase inhibitors. It works by blocking the action of an abno… Read the full Asciminib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Mumps Virus Vaccine, Live Typhoid Vaccine Measles Virus Vaccine, Live Rubella Virus Vaccine, Live Varicella Virus Vaccine, Live

10 Contraindicated 137 Major 7 Moderate

All (154) Contraindicated (10) Major (137) Moderate (7)

Contraindicated

Asciminib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Asciminib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Asciminib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Asciminib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Asciminib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Asciminib Clindamycin ANTIROBE Explained Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Colchicine Colcrys Explained Increased exposure to CYP3A4/P-gp substrates and increased risk of CYP3A4/P-gp substrates-related adverse effects Details Asciminib Simvastatin Flolipid Explained Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Asciminib Abemaciclib Verzenio Explained Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Acalabrutinib Calquence Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Alpelisib Piqray Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Asciminib Adagrasib Krazati Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Asciminib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Asciminib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Asciminib Alfentanil Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Asciminib Artemether Increased artemether/lumefantrine exposure, an increased risk of QT prolongation, reduced CYP3A4 substrate exposure and reduced ef... Details Asciminib Astemizole Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Asciminib Axitinib Inlyta Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Belzutifan Welireg Increased belzutifan exposure and an increased risk of belzutifan-related adverse reactions Details Asciminib Boceprevir Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Asciminib Bosutinib Bosulif Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Brigatinib Alunbrig Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Carbamazepine Carbatrol Reduced asciminib exposure and reduced efficacy of asciminib Details Asciminib Ceritinib Zykadia Increased asciminib exposure, increased CYP3A4 substrate exposure, increased risk of asciminib-related adverse effects and an incr... Details Asciminib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Asciminib Cisapride Propulsid® Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Clarithromycin Biaxin Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Asciminib Cobicistat Tybost Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Asciminib Cobimetinib Cotellic Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Conivaptan Vaprisol Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Crizotinib Xalkori Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Asciminib Cyclosporine Atopica Increased exposure to CYP3A4/P-gp substrates and increased risk of CYP3A4/P-gp substrates-related adverse effects Details Asciminib Dasatinib Phyrago Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.