Ascorbic Acid (Vitamin C)

22 interactions 169 cited references
Also sold as: C-500® Chewable Tablet C-Time® Cecon® Drops Centrum® Singles-Vitamin C Cevi-Bid® Halls Defense® Sunkist® Vitamin C
About Ascorbic Acid (Vitamin C)

Ascorbic acid is a vitamin supplement used to prevent and treat vitamin C deficiency and scurvy. Read the full Ascorbic Acid (Vitamin C) drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amygdalin Bleomycin Deferoxamine Doxycycline Erythromycin Kanamycin
8 Major 7 Moderate 7 Minor
All (22) Major (8) Moderate (7) Minor (7)

Major

Ascorbic Acid (Vitamin C) Amygdalin Increased metabolism of amygdalin, leading to increased cyanide levels Details Ascorbic Acid (Vitamin C) Bleomycin Blenoxane® Decreased bleomycin efficacy Details Ascorbic Acid (Vitamin C) Deferoxamine Impairment of cardiac function Details Ascorbic Acid (Vitamin C) Doxycycline Acticlate Decreased doxycycline efficacy Details Ascorbic Acid (Vitamin C) Erythromycin Erythrocin Stearate Decreased erythromycin efficacy Details Ascorbic Acid (Vitamin C) Kanamycin Decreased kanamycin efficacy Details Ascorbic Acid (Vitamin C) Lincomycin Decreased lincomycin efficacy Details Ascorbic Acid (Vitamin C) Streptomycin Decreased streptomycin efficacy Details

Moderate

Ascorbic Acid (Vitamin C) Amphetamine Dexedrine Decreased blood levels and effectiveness of amphetamines Details Ascorbic Acid (Vitamin C) Benzphetamine Decreased blood levels and effectiveness of amphetamines Details Ascorbic Acid (Vitamin C) Dextroamphetamine Dexedrine Decreased blood levels and effectiveness of amphetamines Details Ascorbic Acid (Vitamin C) Ethinyl Estradiol Increased ethinyl estradiol exposure Details Ascorbic Acid (Vitamin C) Indinavir Decreased indinavir plasma concentrations Details Ascorbic Acid (Vitamin C) Lisdexamfetamine Arynta Decreased blood levels and effectiveness of amphetamines Details Ascorbic Acid (Vitamin C) Methamphetamine Desoxyn Decreased blood levels and effectiveness of amphetamines Details

Minor

Ascorbic Acid (Vitamin C) Aluminum Carbonate, Basic Aluminum toxicity (personality changes, seizures, coma) Details Ascorbic Acid (Vitamin C) Aluminum Hydroxide AlternaGEL® Aluminum toxicity (personality changes, seizures, coma) Details Ascorbic Acid (Vitamin C) Aluminum Phosphate Aluminum toxicity (personality changes, seizures, coma) Details Ascorbic Acid (Vitamin C) Cyanocobalamin Dodex Reduced amounts of cyanocobalamin available for serum and body stores Details Ascorbic Acid (Vitamin C) Dihydroxyaluminum Aminoacetate Aluminum toxicity (personality changes, seizures, coma) Details Ascorbic Acid (Vitamin C) Dihydroxyaluminum Sodium Carbonate Aluminum toxicity (personality changes, seizures, coma) Details Ascorbic Acid (Vitamin C) Magaldrate Aluminum toxicity (personality changes, seizures, coma) Details

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