Asenapine Transdermal Patch

377 interactions 1 explained in plain English 412 cited references
Also sold as: Secuado Secuado®
About Asenapine Transdermal Patch

Asenapine transdermal patches are used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Asenapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain… Read the full Asenapine Transdermal Patch drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Metoclopramide Pimozide Piperaquine Bepridil
15 Contraindicated 276 Major 86 Moderate
All (377) Contraindicated (15) Major (276) Moderate (86)

Major

Asenapine Transdermal Patch Ponesimod Ponvory An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Posaconazole Noxafil An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Potassium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Asenapine Transdermal Patch Pregabalin Bonqat An increased risk of respiratory depression Details Asenapine Transdermal Patch Primidone Mysoline An increased risk of QT interval prolongation and an increased risk of CNS depression Details Asenapine Transdermal Patch Probucol Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Procainamide Procan® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Prochlorperazine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Promethazine Phenadoz An increased risk of QT interval prolongation and an increased risk of CNS depression Details Asenapine Transdermal Patch Propafenone Rythmol Increased propafenone exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Asenapine Transdermal Patch Protriptyline Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Quetiapine Seroquel An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Quinidine Cardioquin® Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Quinine Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Quizartinib Vanflyta An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ranolazine Aspruzyo Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Relugolix Orgovyx Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Remifentanil Increased risk of CNS depression and an increased risk of hypotension Details Asenapine Transdermal Patch Remimazolam Byfavo Increased risk of profound sedation, respiratory depression, coma, and death Details Asenapine Transdermal Patch Revumenib Revuforj An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ribociclib Kisqali An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Asenapine Transdermal Patch Risperidone Perseris Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Ritonavir Norvir Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Rofecoxib Increased asenapine exposure Details Asenapine Transdermal Patch Ropeginterferon Alfa-2B-Njft Besremi Increased risk of sedation Details Asenapine Transdermal Patch Scopolamine Pamine Increased or potentiated scopolamine effects and an increased risk of CNS depression Details Asenapine Transdermal Patch Selpercatinib Retevmo Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sertindole Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sertraline An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sevoflurane Petrem Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Siponimod Mayzent An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sodium Oxybate Lumryz An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Asenapine Transdermal Patch Sodium Phosphate OsmoPrep Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sodium Phosphate, Dibasic Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sodium Phosphate, Monobasic Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Solifenacin Vesicare Increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sorafenib Nexavar An increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sotalol Betapace An increased risk of hypotension and an increased risk of QT interval prolongation Details Asenapine Transdermal Patch Sufentanil Dsuvia Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.