Asenapine

106 interactions 7 explained in plain English

Also sold as: Saphris Secuado

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Morphine Injection Galantamine Oxaliplatin Injection Famotidine

2 Contraindicated 79 Major 25 Moderate

All (106) Contraindicated (2) Major (79) Moderate (25)

Major

Asenapine Galantamine Razadyne Increased risk of QT interval prolongation Details Asenapine Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Asenapine Gefitinib Iressa Increased exposure of CYP2D6 substrate and inhibitor and an increased asenapine exposure Details Asenapine Gemifloxacin Factive Increased risk of QT interval prolongation Details Asenapine Glasdegib Daurismo Increased risk of QT interval prolongation Details Asenapine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Asenapine Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Asenapine Granisetron Injection Granisol Increased risk of QT interval prolongation Details Asenapine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Asenapine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Asenapine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Asenapine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Asenapine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Asenapine Ivabradine Corlanor Increased risk of QT prolongation Details Asenapine Ketoconazole Topical Extina® Foam Increased risk for QT interval prolongation Details Asenapine Lacosamide Injection Motpoly An increased risk of CNS depression Details Asenapine Lefamulin Xenleta Increased risk of QT interval prolongation Details Asenapine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Asenapine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Asenapine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Asenapine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Asenapine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Asenapine Mefloquine Lariam® Increased risk of QT interval prolongation Details Asenapine Metronidazole Flagyl An increased risk of QT interval prolongation Details Asenapine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Asenapine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Asenapine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Asenapine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Asenapine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Asenapine Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Asenapine Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Asenapine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Asenapine Octreotide Bynfezia Increased risk of QT interval prolongation Details Asenapine Octreotide Injection Bynfezia Increased risk of QT interval prolongation Details Asenapine Ofloxacin Floxin® Increased risk of QT interval prolongation Details Asenapine Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation Details Asenapine Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation Details Asenapine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Asenapine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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