Asenapine

106 interactions 7 explained in plain English

Also sold as: Saphris Secuado

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Morphine Injection Galantamine Oxaliplatin Injection Famotidine

2 Contraindicated 79 Major 25 Moderate

All (106) Contraindicated (2) Major (79) Moderate (25)

Contraindicated

Asenapine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Asenapine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Asenapine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Asenapine Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Asenapine Sertraline Explained An increased risk of QT interval prolongation Details Asenapine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Asenapine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Asenapine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Asenapine Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Asenapine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Asenapine Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Asenapine Azithromycin AzaSite Increased risk of QT interval prolongation and torsade de pointes Details Asenapine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Asenapine Alfuzosin UroXatral An increased risk of QT interval prolongation and an increased risk of hypotension Details Asenapine Anagrelide Agrylin Increased risk of QT interval prolongation Details Asenapine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Asenapine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Asenapine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Asenapine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Asenapine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Asenapine Chloroquine Aralen® Increased risk of QT interval prolongation Details Asenapine Dasatinib Phyrago An increased risk of QT interval prolongation Details Asenapine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Asenapine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Asenapine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Asenapine Diazepam Rectal Diastat Increased risk of CNS depression Details Asenapine Disopyramide Norpace Increased risk of QT interval prolongation Details Asenapine Dofetilide Tikosyn Increased risk of QT interval prolongation Details Asenapine Dolasetron Anzemet Increased risk of QT interval prolongation Details Asenapine Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Asenapine Enasidenib Idhifa Increased asenapine exposure Details Asenapine Encorafenib Braftovi Increased risk of QT interval prolongation Details Asenapine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Asenapine Eribulin Injection Halaven Increased risk of QT interval prolongation Details Asenapine Esketamine Nasal Spray Spravato Increased risk of sedation Details Asenapine Famotidine Calmicid Increased risk of QT interval prolongation Details Asenapine Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Asenapine Felbamate Felbatol Increased risk of QT interval prolongation Details Asenapine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Asenapine Flecainide Tambocor® Increased flecainide exposure, an increased asenapine exposure, an increased risk of QT interval prolongation and an increased ris... Details

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