Drug & supplement interaction

Moringa + Asenapine

Asenapine brand names: Saphris, Secuado.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Moringa has a minor interaction with Asenapine. Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Moringa and Asenapine

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Asenapine

Asenapine falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Moringa interacts with.

Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that moringa extract induces CYP1A2 enzymes.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for asenapine (Saphris, Secuado). Your body clears this medicine partly through a liver enzyme called CYP1A2. In lab dish studies, moringa appears to speed up that enzyme. If that held true in people, moringa could lower asenapine levels, which might make it work a little less well. For someone managing schizophrenia or bipolar mania, that could theoretically mean symptoms slipping back, like mood swings, agitation, or returning unusual thoughts.

That said, I want to be straight with you: this is only based on test-tube research, not real patients, and it's rated a minor, possible interaction. Everyday culinary amounts of moringa are unlikely to cause trouble. Still, before adding concentrated moringa supplements, check in with your pharmacist or doctor so they can keep an eye on how you're doing.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Moringa Also Interacts With Other Medications

Moringa has 717 moderate, 151 minor known drug interactions in our database — the Asenapine one above is one of them. If you take anything else, check it against the full list below.

Moderate 717 Minor 151 No known interaction 1,962 (incl. Asenapine)
Taking anything else?

Check Another of Your Medications Against Moringa

Covers the 2,830 medications we’ve checked against Moringa. Pick one to open its full report.

From our Q&A

Questions About Moringa or Asenapine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Moringa or Asenapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Asenapine

This page covers Moringa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Asenapine page lists 122 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 78 moderate · 35 minor.

From our pharmacist’s overview on the Asenapine page

“The heart rhythm risk is the one to understand first. Asenapine (Saphris, Secuado), an antipsychotic for schizophrenia and bipolar disorder, can affect the QT interval, the electrical reset between heartbeats, and 13 ingredients on this list can prolong it too, including everyday grapefruit.”

Reviewed by 2 · Jul 18, 2026

Open the Asenapine interaction page

One more smart check

Taking Moringa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 738 real supplement products containing Moringa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Moringa. Your product may carry other ingredients that interact with Asenapine too, on top of Moringa — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Moringa and Asenapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Moringa
Top 25%

#201 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Asenapine
Steady interest

#2,133 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Moringa

What is Moringa?

  • Nutritional supplement
  • Blood sugar support
  • Cholesterol support
  • Inflammation
  • Skin conditions

Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition is common. Early research hints at possible benefits for blood sugar, cholesterol, and inflammation, but the human evidence is limited and not strong enough to recommend it as a treatment. Talk with your pharmacist or doctor before using moringa, especially if you are pregnant, breastfeeding, or taking medications.

Read the full Moringa monograph & all interactions
Medication

About Asenapine

What Is Asenapine Used For?

Brand names: Saphris, Secuado

Asenapine treats schizophrenia in adults and bipolar I disorder (manic or mixed episodes) in adults and in children ages 10 to 17. It can be used alone or alongside lithium or valproate in adults with bipolar I disorder.

The sublingual tablet forms (Saphris and the generic asenapine sublingual tablet) are approved for both schizophrenia and bipolar I disorder. Secuado, the skin patch, is approved only for schizophrenia in adults.

See full Asenapine drug information
Keep checking

Other Drugs & Moringa

Browse every other medication we’ve checked against Moringa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
717Moderate
151Minor
1,961No known interaction
717 Moderate 151 Minor 1,961 No interaction
Moderate

717 interactions

Showing 60 of 717 moderate interactions — see all 717 on the Moringa page.

Minor

151 interactions

Showing 60 of 151 minor interactions — see all 151 on the Moringa page.

No interaction 1,961 drugs checked — show the list

We also checked Moringa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,961 medications checked with no known interaction — see the full Moringa list.

See the full Moringa interactions page
See every supplement checked against Asenapine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Moringa monograph › Uses, safety, and every drug interaction in one place Asenapine supplement interactions › Every supplement checked against Asenapine, ranked by severity Asenapine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Moringa and Asenapine Together: Common Questions

Can you take Moringa with Asenapine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Moringa and Asenapine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Asenapine and Moringa?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.