Medication interaction hub

What Supplements Interact with Asenapine?

Asenapine brand names: Saphris, Secuado. Every interaction below applies to the brands too.

122 Interactions 9 Major 78 Moderate 35 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Asenapine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Asenapine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The heart rhythm risk is the one to understand first. Asenapine (Saphris, Secuado), an antipsychotic for schizophrenia and bipolar disorder, can affect the QT interval, the electrical reset between heartbeats, and 13 ingredients on this list can prolong it too, including everyday grapefruit. Stacking them raises the chance of a dangerous arrhythmia, so I read this page as a genuine warning. Nine of the 122 ingredients rate major, and most of those nine sit in that QT group.

The wider list is quieter but worth knowing. Nearly 80 ingredients touch CYP1A2, the liver enzyme that clears asenapine, and can nudge its level up or down; those sit among the 78 moderate and 35 minor entries. A few herbs such as Indian snakeroot can amplify antipsychotic effects. And activated charcoal, another of the majors, can soak up an oral dose before it absorbs, so keep the two well spaced.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 78 Minor 35 No known interaction 1,330

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Asenapine: Top Interactions at a Glance

The Asenapine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 122 interacting ingredients — plus 1,330 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Asenapine Combinations Today

The Asenapine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Ashwagandha + Asenapinei

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Asenapinei

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Read the full interaction Moderate Likelihood Possible Dandelion + Asenapinei

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Cowhage + Asenapinei

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Asenapinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Asenapinei

Arsenic trioxide can prolong the QT interval.

Read the full interaction
The complete list

Every Supplement Checked Against Asenapine

All 1,452 ingredients in our database, ranked by severity — 122 with a Asenapine interaction on file and 1,330 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Asenapine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.

Full Ashwagandha + Asenapine answer

Can you take Sida Cordifolia with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Asenapine answer

Can you take Dandelion with Asenapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Asenapine answer

Can you take Cowhage with Asenapine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.

Full Cowhage + Asenapine answer

Can you take Yohimbe with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Yohimbe + Asenapine answer

Can you take Cannabis with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Cannabis does not seem to affect blood levels or effects of some antipsychotic drugs.

Full Cannabis + Asenapine answer

Can you take Chrysin with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, chrysin might increase levels of drugs metabolized by CYP1A2.

Full Chrysin + Asenapine answer

Can you take Diindolylmethane with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.

Full Diindolylmethane + Asenapine answer

Can you take Hops with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Hops extract does not seem to affect the metabolism of CYP1A2 substrates.

Full Hops + Asenapine answer

Can you take Kava with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Asenapine answer

Can you take Red Clover with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.

Full Red Clover + Asenapine answer

Can you take Rosemary with Asenapine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.

Full Rosemary + Asenapine answer

Can you take Activated Charcoal with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Asenapine answer

Can you take Arsenic with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Asenapine answer

Can you take Cesium with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Asenapine answer

Can you take Ephedra with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Asenapine answer

Can you take Grapefruit with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT inte...

Full Grapefruit + Asenapine answer

Can you take Indian Snakeroot with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk of adverse effects.

Full Indian Snakeroot + Asenapine answer

Can you take Rauvolfia Vomitoria with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might increase the risk of adverse effects.

Full Rauvolfia Vomitoria + Asenapine answer

Can you take American Hellebore with Asenapine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Asenapine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Asenapine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Asenapine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Asenapine sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Asenapine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Asenapine through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Asenapine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Asenapine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Asenapine through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Asenapine through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Asenapine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Asenapine through this category.

About Asenapine

Asenapine is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder in adults, available as a sublingual tablet and as the Secuado transdermal patch.

Generic name: Asenapine  ·  Brand names: Saphris, Secuado.

See the full Asenapine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Asenapine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Asenapine.

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Pharmacist Counseling Corner

Asenapine & Supplements: Common Questions

What supplements interact with Asenapine?
More than you might expect — 122 in total, though they are far from equal: 9 are rated major, 78 moderate, and 35 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Arsenic, Cesium.
Which Asenapine supplement interactions are the most serious?
The 9 major-rated combinations — led by Activated Charcoal, Arsenic, Cesium, Ephedra and Grapefruit — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Asenapine?
Usually yes — most people on Asenapine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Saphris have the same supplement interactions as Asenapine?
Yes — Saphris, Secuado all contain Asenapine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Asenapine and my other medications?
This page covers Asenapine against supplements and herbal ingredients. Checking Asenapine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Asenapine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.