Drug & supplement interaction

Moringa + Pregabalin

Pregabalin brand names: Lyrica, Lyrica CR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Moringa and Pregabalin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Moringa and Pregabalin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pregabalin and Moringa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Moringa safety at a glance

Moringa overall Use caution Leaf products appear generally well tolerated as food, but high-quality safety data are limited.
Pregnancy Possibly Safe When the leaf is used orally during the second or third trimesters, short-term. Moringa leaf powder or extract 500 mg daily for up to 4 months has been used wit... Read the full pregnancy detail
Breastfeeding Possibly Safe When moringa leaf is used orally, short-term. Moringa leaf powder or extract 2 grams daily has been used during lactation with apparent safety for up to 4 month... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pregabalin and Moringa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pregabalin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pregabalin is filed under 3 classifications — including cns depressants, oral drugs. Moringa has documented interactions with 6 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), levothyroxine (synthroid, others) (moderate) and p-glycoprotein substrates (moderate) — and none of Pregabalin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Moringa Does Interact With Other Medications

Moringa has 717 moderate, 152 minor known drug interactions in our database — Pregabalin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 717 Minor 152 No known interaction 1,961 (incl. Pregabalin)
Taking anything else?

Check Another of Your Medications Against Moringa

Covers the 2,830 medications we’ve checked against Moringa. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Moringa and Pregabalin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

  • Blood clots Worth acting on Additional detail

    Moringa

    “Orally, a case of bilateral pulmonary embolism after a 5-month history of taking moringa leaf extract is reported in a 63-year-old female without other risks for venous thromboembolism. The patient recovered with standard anticoagulant treatment. Researchers speculate that possible procoagulant effects of moringa may have played a role in this event.”

    Moringa · Natural Medicines adverse-effect record, reported in venous thromboembolism (vte).

    1 source cited
    1. 110644. Ebhohon E, Miller D. Moringa Oleifera leaf extract induced pulmonary embolism-a case report. Int J Emerg Med 2022;15(1):16. PubMed

    Pregabalin

    Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

  • A severe skin reaction Worth acting on Additional detail

    Moringa

    “Orally, Stevens-Johnson syndrome has been linked to the consumption of moringa leaves. A 53-year-old male presented with fever and generalized maculopapular rash 14 hours after eating food containing moringa leaves. Painful oral ulcers developed by the next day. The patient also reported a similar episode of oral ulcers after eating food containing moringa leaves three months earlier.”

    Moringa · Natural Medicines adverse-effect record, reported in traumatic oral ulcers.

    2 sources cited
    1. 99876. Witharana EWRA, Wijetunga WMGASTB, Wijesinghe SKJ. Stevens - Johnson syndrome (SJS) following murunga leaf (Moringa oleifera) consumption. Ceylon Med J 2018;63(4):188-9.
    2. 112641. Amsler E, Mahevas T, Soria A, Barbaud A. Fixed food eruption to Moringa oleifera. Contact Dermatitis 2023;89(4):301-302.

    Pregabalin

    Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    Moringa

    “Orally and topically, moringa leaf and seed seem to be well tolerated. Orally, moringa root and root bark might be unsafe. However, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Transient diarrhea.

    Serious Adverse Effects (Rare):

    Orally: Allergic reactions, including anaphylaxis, have been reported.”

    Moringa · Natural Medicines adverse-effect record, reported in diarrhea.

    Pregabalin

    Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

  • Mouth irritation or sores / Fever / A skin rash Additional detail

    Moringa

    Recorded for Moringa in the same Natural Medicines adverse-effect record shown under A severe skin reaction above.

    Pregabalin

    Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Moringa

    “Orally, moringa leaf powder can cause diarrhea. In a clinical trial, taking moringa leaf powder 8 grams daily resulted in transient diarrhea in 4 of 16 patients (25%).”

    Moringa · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 105470. Taweerutchana R, Lumlerdkij N, Vannasaeng S, Akarasereenont P, Sriwijitkamol A. Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy-Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study. Evid Based Complement Alternat M

    Pregabalin

    Listed in the ADVERSE REACTIONS section of the FDA label for Pregabalin. Read the label on DailyMed ›

Effects for Pregabalin come from the ADVERSE REACTIONS section of its FDA label; effects for Moringa come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Moringa in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When the leaf is used orally during the second or third trimesters, short-term. Moringa leaf powder or extract 500 mg daily for up to 4 months has been used with apparent safety during the second and third trimesters. There is insufficient reliable information available about the safety of using moringa leaf by mouth during the first trimester.

Pregnancy Possibly Unsafe

When the root, bark, or flower are used orally. Traditionally, moringa root bark and gum from moringa trunk bark have been used to induce abortion. When taken orally along with black peppercorns to induce abortion, moringa root bark may cause fatality. Animal research shows that moringa flower can cause uterine contractions; however, this has not been assessed in humans. There is insufficient reliable information about the safety of using moringa seed during pregnancy; avoid using.

Lactation Possibly Safe

When moringa leaf is used orally, short-term. Moringa leaf powder or extract 2 grams daily has been used during lactation with apparent safety for up to 4 months. There is insufficient reliable information available about the safety of using other parts of moringa during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Pregabalin Is Prescribed For, and What Moringa Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Pregabalin is a prescription medicine with approved uses on its FDA label. Moringa is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Pregabalin is prescribed for: Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury. Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.

Moringa has been studied for:

  • Diabetes studied, not established Moringa has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Moringa for diabetes

    It is unclear if oral moringa leaf is beneficial in patients with diabetes; research is conflicting.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Pregabalin on your own; if you are taking Moringa for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Moringa or Pregabalin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Moringa or Pregabalin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Pregabalin

This page covers Moringa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pregabalin page lists 95 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 73 moderate · 15 minor.

From our pharmacist’s overview on the Pregabalin page

“Pregabalin (Lyrica) calms overactive nerves, which is how it eases nerve pain, seizures, and anxiety, and that calming action stacks with almost everything on this list. Of the 95 supplements and herbs, the large majority add their own sedation on top of pregabalin's, and a few can tip that into genuine danger, with deep sedation and s…”

Reviewed by 2 · Jul 18, 2026

Open the Pregabalin interaction page

One more smart check

Taking Moringa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 738 real supplement products containing Moringa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Moringa. Even though Moringa itself has no known interaction with Pregabalin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Moringa and Pregabalin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Moringa
Top 25%

#200 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pregabalin
Top 5%

#40 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Moringa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Moringa and Pregabalin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Moringa

What is Moringa?

  • Nutritional supplement
  • Blood sugar support
  • Cholesterol support
  • Inflammation
  • Skin conditions

Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition is common. Early research hints at possible benefits for blood sugar, cholesterol, and inflammation, but the human evidence is limited and not strong enough to recommend it as a treatment. Talk with your pharmacist or doctor before using moringa, especially if you are pregnant, breastfeeding, or taking medications.

Moringa oleifera · Moringaceae · Leaves, seeds, seed pods, seed oil, bark, and roots · Capsules, powder, tea, dried leaf, seed oil

An interaction check asks whether these two react with each other — it does not ask whether Moringa is a good idea for someone in your situation. Here is what our Moringa record says about it on its own.

Moringa: dosing

There is no well-established standard dose for moringa. Studies have used different forms and amounts, so it is hard to recommend a single dose.If you choose to use a moringa supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Moringa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Moringa monograph & all interactions
Medication

About Pregabalin

What Is Pregabalin Used For?

Brand names: Lyrica, Lyrica CR

Pregabalin is used to manage several types of nerve pain, including neuropathic pain from diabetic peripheral neuropathy (nerve damage caused by diabetes) and postherpetic neuralgia (lingering nerve pain after shingles). It is also used to treat fibromyalgia and neuropathic pain associated with spinal cord injury.

Lyrica (capsule and oral solution), pregabalin capsules, and pregabalin oral solution are also approved as add-on therapy for partial-onset seizures — Lyrica for patients 1 month and older, and pregabalin capsules for patients 17 years and older. Lyrica CR and pregabalin extended-release tablets are approved only for diabetic peripheral neuropathy pain and postherpetic neuralgia — their effectiveness for fibromyalgia or as seizure add-on therapy has not been established.

Most-Reported Side Effects for Pregabalin

From FAERS, the FDA’s public side-effect reporting system (270,557 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 15,629 reports
Dizziness 14,844 reports
Nausea 14,507 reports
Headache 13,067 reports
Malaise 12,884 reports
See full Pregabalin drug information
Keep checking

Other Drugs & Moringa

Browse every other medication we’ve checked against Moringa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
717Moderate
152Minor
1,960No known interaction
717 Moderate 152 Minor 1,960 No interaction
Moderate

717 interactions

Showing 60 of 717 moderate interactions — see all 717 on the Moringa page.

Minor

152 interactions

Showing 60 of 152 minor interactions — see all 152 on the Moringa page.

No interaction 1,960 drugs checked — show the list

We also checked Moringa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,960 medications checked with no known interaction — see the full Moringa list.

See the full Moringa interactions page
See every supplement checked against Pregabalin, ranked by severity
Evidence & sources

Moringa References

The 23 references that drive our Moringa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84:105-8. PubMed
  2. Tahiliani P, Kar A. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol Res 2000;41:319-23. PubMed
  3. Jaiswal D, Kumar Rai P, Kumar A, et al. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmcol 2009;123:392-6. PubMed
  4. Bour S, Visentin V, Prevot D, et al. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats. J Physiol Biochem 2005;61:371-9. PubMed
  5. Iffiu-Soltesz Z, Wanecq E, Lomba A, et al. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. Pharmacol Res 2010;61:355-63. PubMed
  6. Monera TG, Wolfe AR, Maponga CC, et al. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries 2008;2:379-83.
  7. Estrella M, Mantaring J, David G, Taup M. A double blind, randomised controlled trial on the use of malunggay (Moringa oleifera) for augmentation of the volume of breastmilk among non-nursing mothers of preterm infants. Philipp J Pediatr 2000;49:3-6.
  8. Morton, J. F. The Horseradish Tree, Moringa Pterygosperma (Moringaceae) - a boon to arid lands? Economic Botany 1991;45:318-333. DOI
  9. Espinosa-Kuo CL. A Randomized Controlled Trial on the Use of Malunggay (Moringa oleifera) for Augmentation of the Volume of Breastmilk Among Mothers of Term Infants. Filipino Family Physician. 2005;43(1):26-33.
  10. King JS, Raguindin PFN, Dans LF. Moringa oleifera (Malunggay) as a Galactagogue for Breastfeeding Mothers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Philipp J Pediatr 2013;61(2):34-42.
  11. Singh D, Choudhury S, Singh TU, Garg SK. Pharmacodynamics of uterotonic effect of Moringa oleifera flowers extract. J Vet Pharmcol Toxicol 2008;7(1-2):12-15.
  12. William F, Lakshminarayanan S, Chegu H. Effect of some Indian vegetables on the glucose and insulin response in diabetic subjects. International Journal of Food Sciences and Nutrition 1993;44(3): 191-195. DOI: 10.3109/09637489309017439 DOI
  13. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017;14:12. doi: 10.1186/s1 PubMed
  14. Witharana EWRA, Wijetunga WMGASTB, Wijesinghe SKJ. Stevens - Johnson syndrome (SJS) following murunga leaf (Moringa oleifera) consumption. Ceylon Med J 2018;63(4):188-9.
  15. Nur R, Demak IPK, Radhiah S, Rusydi M, Mantao E, Larasati RD. The effect of moringa leaf extracton increasing hemoglobin and bodyweight in post-disaster pregnant women. Enferm Clin. 2020;30 Suppl 4:79-82. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Moringa and Pregabalin Together: Common Questions

Is it safe to take Moringa with Pregabalin?
We do not list a known interaction between Moringa and Pregabalin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Moringa and Pregabalin have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Moringa and Pregabalin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Moringa in each. That is a conversation for your prescriber, especially if Pregabalin is being adjusted to a target.
How was the Moringa and Pregabalin combination checked?
Interactions in our licensed database are recorded against drug classes. Pregabalin is filed under 3 classifications, and Moringa has documented interactions with 6 drug classes — none of Pregabalin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Moringa interact with any other medications?
Yes. Moringa has 869 documented drug interactions in our database — Pregabalin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pregabalin interact with any supplements?
Yes. Pregabalin has documented interactions with 95 supplements in our database — Moringa is not one of them. The Pregabalin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Moringa monograph Uses, safety profile, and every drug interaction in one place Pregabalin drug information The full plain-English guide to this medication Pregabalin supplement interactions Every supplement checked against Pregabalin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 23 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pregabalin and Moringa?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.