Asenapine

106 interactions 7 explained in plain English
Also sold as: Saphris Secuado
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Morphine Injection Galantamine Oxaliplatin Injection Famotidine
2 Contraindicated 79 Major 25 Moderate
All (106) Contraindicated (2) Major (79) Moderate (25)

Moderate

Asenapine Lisinopril Prinivil Explained An increased risk of hypotension Details Asenapine Atenolol Tenormin Explained An increased risk of hypotension Details Asenapine Acebutolol Sectral® An increased risk of hypotension Details Asenapine Benazepril Lotensin An increased risk of hypotension Details Asenapine Azilsartan Edarbi An increased risk of hypotension Details Asenapine Betaxolol Betoptic S An increased risk of hypotension Details Asenapine Betaxolol Ophthalmic Betoptic® An increased risk of hypotension Details Asenapine Bisoprolol Zebeta® An increased risk of hypotension Details Asenapine Captopril Capoten® An increased risk of hypotension Details Asenapine Clonidine Transdermal Patch Catapres Induction or exacerbation of orthostatic regulation disturbances and an increased risk of sedation and somnolence Details Asenapine Doxazosin Cardura An increased risk of hypotension Details Asenapine Enalapril Epaned An increased risk of hypotension Details Asenapine Eprosartan Teveten® An increased risk of hypotension Details Asenapine Esmolol Brevibloc An increased risk of hypotension Details Asenapine Fosinopril Monopril® An increased risk of hypotension Details Asenapine Furosemide Injection Disal An increased risk of hypotension Details Asenapine Irbesartan Avapro An increased risk of hypotension Details Asenapine Labetalol Normodyne® An increased risk of hypotension Details Asenapine Levobunolol Ophthalmic AKBeta® An increased risk of hypotension Details Asenapine Losartan Arbli An increased risk of hypotension Details Asenapine Moexipril Univasc® An increased risk of hypotension Details Asenapine Nadolol Corgard An increased risk of hypotension Details Asenapine Nebivolol Bystolic An increased risk of hypotension Details Asenapine Penbutolol Levatol® An increased risk of hypotension Details Asenapine Perindopril Aceon An increased risk of hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.