Atazanavir

179 interactions 13 explained in plain English
Also sold as: Reyataz
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Irinotecan Lipid Complex Injection Midazolam Nasal Spray Encorafenib Lovastatin Lurasidone Colchicine
18 Contraindicated 134 Major 27 Moderate
All (179) Contraindicated (18) Major (134) Moderate (27)

Contraindicated

Atazanavir Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Atazanavir Simvastatin Flolipid Explained An increased risk of simvastatin toxicity, including an increased risk of myopathy or rhabdomyolysis Details Atazanavir Alfuzosin UroXatral Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Atazanavir Dihydroergotamine Injection DHE-45® Injection An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Atazanavir Dihydroergotamine Nasal Spray Migranal An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Atazanavir Encorafenib Braftovi Reduced atazanavir exposure, reduced efficacy of atazanavir, increased encorafenib exposure and an increased risk of QT interval p... Details Atazanavir Irinotecan Camptosar Increased irinotecan and its active metabolite, SN-38 exposure Details Atazanavir Irinotecan Injection Camptosar Increased irinotecan and its active metabolite, SN-38 exposure Details Atazanavir Irinotecan Lipid Complex Injection Onivyde® Increased irinotecan and its active metabolite, SN-38 exposure Details Atazanavir Ketoconazole Topical Extina® Foam Increased atazanavir exposure, increased ketoconazole exposure and an increased risk for QT interval prolongation Details Atazanavir Lefamulin Xenleta Increased lefamulin and atazanavir exposure and an increased risk of QT interval prolongation Details Atazanavir Lovastatin Altocor® Increased risk of lovastatin toxicity, including an increased risk of myopathy or rhabdomyolysis Details Atazanavir Lurasidone Latuda Increased lurasidone exposure Details Atazanavir Maraviroc Selzentry Increased exposure of maraviroc Details Atazanavir Methylergonovine Methergine An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Atazanavir Midazolam Nasal Spray Nayzilam Increased midazolam exposure Details Atazanavir Midazolam Injection Nayzilam Increased midazolam exposure Details Atazanavir Nevirapine Viramune Reduced atazanavir exposure, an increased risk of virologic failure, increased nevirapine exposure and an increased risk of nevira... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.