Atogepant and Boceprevir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Boceprevir
No brand names on recordAtogepant
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered atogepant exposure
Interaction Deep Dive
Coadministration of atogepant with a strong CYP3A4 inhibitor that is also a CYP3A4 inducer may significantly reduce atogepant exposure or may increase atogepant exposure. In a pharmacokinetic study, coadministration of atogepant with steady-state rifAMPin (a strong CYP3A4 inducer) reduced atogepant AUC by 60% and Cmax by 30% in healthy subjects. And, coadministration of atogepant with itraconazole (strong CYP3A4 inhibitor) increased atogepant AUC by 5.5-fold and Cmax by 2.15-fold in healthy subjects. For episodic migraine, the recommended dosage of atogepant with concomitant use of a strong CYP3A4 inhibitor that is also a CYP3A4 inducer is 10 mg once daily. For chronic migraine, avoid concomitant use of a strong CYP3A4 inhibitor that is also a CYP3A4 inducer with atogepant1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of atogepant; induction of CYP3A4-mediated metabolism of atogepant
Literature reports
3 reports — tap to read
a) In a pharmacokinetic study, coadministration of atogepant with steady-state rifAMPin (a strong CYP3A4 inducer) reduced atogepant AUC by 60% and Cmax by 30% in healthy subjects 1.
b) In a pharmacokinetic study, coadministration of atogepant with itraconazole (strong CYP3A4 inhibitor) increased atogepant AUC by 5.5-fold and Cmax by 2.15-fold in healthy subjects 1.
c) Population pharmacokinetic modeling predicts coadministration of atogepant with a moderate or weak CYP3A4 inhibitor will increase atogepant AUC by 1.7- and 1.1-fold, respectively. This suggested change in atogepant exposure is not expected to be clinically relevant 1.
Common questions
Can I take Atogepant and Boceprevir together?
Altered atogepant exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Atogepant and Boceprevir interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Atogepant or Boceprevir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: QULIPTA(R) oral tablets, atogepant oral tablets. AbbVie Inc (per FDA), North Chicago, IL, 2025. DailyMed
Keep reading about Boceprevir
Keep reading about Atogepant
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