Atorvastatin and Haloperidol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 15, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Atorvastatin
Haloperidol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation
Interaction Deep Dive
Coadministration of haloperidol (CYP3A substrate)1 and atorvastatin (weak CYP3A4 inhibitor) 2 may increase haloperidol exposure, which may increase haloperidol-related adverse events, including QTc interval prolongation. If concomitant use is required, monitor for signs or symptoms of increased or prolonged pharmacologic effects of haloperidol and reduce haloperidol dosage if necessary 1. Additionally, myalgia associated with coadministration of atorvastatin and haloperidol was described in a case report 3.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of haloperidol
Literature reports
1 report — tap to read
a) Occurrences of adverse events attributed to drug interactions between antipsychotic drugs (used for schizophrenia or bipolar disorder) and drugs used for the treatment of cardiovascular diseases were evaluated in a study using data collected between January 2, 2017 to March 30, 2018 from the University Center for Clinical Drug Adverse Effects Monitoring and Study at the Clinic of Pharmacology of the Jagiellonian University Medical College (N=52 cases). The cause-effect relationship was either probable (n=41) or certain (n=11) for all evaluated cases within the study. Twelve cases reported interactions between antipsychotics and statins, with most describing signs or symptoms of muscle disorders. Specifically, 1 case described a 74-year-old female patient that experienced myalgia with coadministration of atorvastatin and haloperidol. The suspected mechanism was inhibition of atorvastatin metabolism 3.
Common questions
Can I take Atorvastatin and Haloperidol together?
Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Atorvastatin and Haloperidol interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Atorvastatin or Haloperidol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Product Information: HALDOL(R) Decanoate 100 intramuscular injection, haloperidol decanoate intramuscular injection. Janssen Pharmaceuticals Inc (per FDA), Titusville, NJ, 2025.
- Certara Drug Interactions Solutions: Certara Drug Interaction Database (DIDB(R)). Princeton, NJ: Certara, May 2024.
- Siwek M, Woron J, Gorostowicz A, et al: Adverse effects of interactions between antipsychotics and medications used in the treatment of cardiovascular disorders. Pharmacol Rep 2020; 72(2):350-359. PubMed
Keep reading about Atorvastatin
Keep reading about Haloperidol
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