Atovaquone

19 interactions 123 cited references
Also sold as: Mepron Mepron®
About Atovaquone

Atovaquone is used to treat Pneumocystis jiroveci [Pneumocystis carinii] pneumonia (PCP; type of pneumonia most likely to affect people with human immunodeficiency virus [HIV]) in teenagers and adults. Atovaquone is also used to prevent PCP in teenagers and adults who cannot take another medication used for prevention.… Read the full Atovaquone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Bupropion Clomipramine Efavirenz Hydroxychloroquine Levoketoconazole
14 Major 5 Moderate
All (19) Major (14) Moderate (5)

Major

Atovaquone Azathioprine Azasan An increased risk of hepatotoxicity Details Atovaquone Bupropion Aplenzin Increased risk of seizures Details Atovaquone Clomipramine Anafranil Increased risk of seizures Details Atovaquone Efavirenz Reduced atovaquone exposure Details Atovaquone Hydroxychloroquine Plaquenil An increased risk of seizures Details Atovaquone Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Atovaquone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Atovaquone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Atovaquone Quizartinib Vanflyta An increased risk of QT interval prolongation Details Atovaquone Rifabutin Mycobutin Reduced atovaquone exposure Details Atovaquone Rifampin Rifadin Reduced atovaquone exposure, an increased rifAMPin exposure and an increased risk of rifAMPin-related adverse reactions Details Atovaquone Ritonavir Norvir Decreased atovaquone serum concentrations Details Atovaquone Tramadol ConZip An increased risk of seizure Details Atovaquone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Atovaquone Metoclopramide Reduction of atovaquone bioavailability Details Atovaquone Tetracycline Achromycin V® Reduction of atovaquone plasma concentrations Details Atovaquone Warfarin Coumadin Increased INR Details Atovaquone Metoclopramide Injection Gimoti Reduction of atovaquone bioavailability Details Atovaquone Metoclopramide Nasal Spray Gimoti Reduction of atovaquone bioavailability Details

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