Atovaquone

Name: Atovaquone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

19 interactions 123 cited references

Also sold as: Mepron Mepron®

About Atovaquone

Atovaquone is used to treat Pneumocystis jiroveci [Pneumocystis carinii] pneumonia (PCP; type of pneumonia most likely to affect people with human immunodeficiency virus [HIV]) in teenagers and adults. Atovaquone is also used to prevent PCP in teenagers and adults who cannot take another medication used for prevention.… Read the full Atovaquone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Bupropion Clomipramine Efavirenz Hydroxychloroquine Levoketoconazole

14 Major 5 Moderate

All (19) Major (14) Moderate (5)

Moderate

Atovaquone Metoclopramide Reduction of atovaquone bioavailability Details Atovaquone Tetracycline Achromycin V® Reduction of atovaquone plasma concentrations Details Atovaquone Warfarin Coumadin Increased INR Details Atovaquone Metoclopramide Injection Gimoti Reduction of atovaquone bioavailability Details Atovaquone Metoclopramide Nasal Spray Gimoti Reduction of atovaquone bioavailability Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.