Avapritinib
126 interactions 1 explained in plain English 259 cited referencesAvapritinib is used to treat a certain type of gastrointestinal stromal tumor (GIST; a type of tumor that grows in the wall of the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in adults that has spread to other parts of the body or that cannot be removed by surgery. It is a… Read the full Avapritinib drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Avapritinib Repotrectinib Augtyro Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Ribociclib Kisqali Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Rifabutin Mycobutin Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Rifampin Rifadin Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Ritlecitinib Litfulo Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Avapritinib Ritonavir Norvir Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Avapritinib Saquinavir Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Schisandra Sphenanthera Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Sotorasib Lumakras Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib St John's Wort Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Suzetrigine Journavx Reduced sensitive CYP3A substrate exposure and reduced efficacy of sensitive CYP3A substrate Details Avapritinib Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Avapritinib Telaprevir Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Telithromycin Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Telotristat Ethyl Xermelo Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Thioridazine Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Trofinetide Daybue Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related toxicities Details Avapritinib Troleandomycin Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Tucatinib Tukysa Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Verapamil Calan Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Voriconazole Vfend Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Voxelotor Oxbryta Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Ketoconazole Topical Extina® Foam Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Avapritinib Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Avapritinib Letermovir Injection Prevymis Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Nafcillin Injection Unipen® Injection Reduced avapritinib exposure and reduced efficacy of avapritinib DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist