Avapritinib

126 interactions 1 explained in plain English 259 cited references
Also sold as: Ayvakit Ayvakit®
About Avapritinib

Avapritinib is used to treat a certain type of gastrointestinal stromal tumor (GIST; a type of tumor that grows in the wall of the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in adults that has spread to other parts of the body or that cannot be removed by surgery. It is a… Read the full Avapritinib drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Levoketoconazole Ensitrelvir Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live
11 Contraindicated 108 Major 7 Moderate
All (126) Contraindicated (11) Major (108) Moderate (7)

Major

Avapritinib Adagrasib Krazati Increased CYP3A4 substrate exposure Details Avapritinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Avapritinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Avapritinib Amprenavir Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Apalutamide Erleada Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Aprepitant Aponvie Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Atazanavir Reyataz Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Avapritinib Berotralstat Orladeyo Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Boceprevir Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Bosentan Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Carbamazepine Carbatrol Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Cenobamate Xcopri Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Ceritinib Zykadia Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Avapritinib Ciprofloxacin Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Clarithromycin Biaxin Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Clofazimine Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Cobicistat Tybost Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Avapritinib Conivaptan Vaprisol Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Crizotinib Xalkori Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Avapritinib Darunavir Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Diltiazem Cardizem Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Dipyrone Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Dronedarone Multaq Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Duvelisib Copiktra Increased exposure of sensitive CYP3A4 substrates and risk of toxicity Details Avapritinib Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Avapritinib Efavirenz Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Elagolix Orilissa Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Avapritinib Enzalutamide Xtandi Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Erythromycin Erythrocin Stearate Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Ethinyl Estradiol Increased ethinyl estradiol exposure and an increased risk of ethinyl estradiol-related adverse reactions Details Avapritinib Etravirine Intelence Reduced avapritinib exposure and reduced efficacy of avapritinib Details Avapritinib Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Avapritinib Fexinidazole An increased CYP3A4 substrate exposure Details Avapritinib Fluconazole Diflucan Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Fosamprenavir Lexiva Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Avapritinib Fosnetupitant Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.