Azelastine Nasal Spray

8 interactions 97 cited references
Also sold as: Astelin® Nasal Spray Astepro Astepro Allergy® Nasal Spray Dymista® Nasal Spray (as a combination product containing Fluticasone, Azelastine)
About Azelastine Nasal Spray

Prescription and nonprescription (over the counter) azelastine nasal spray is used to relieve symptoms of rhinitis such as sneezing and a runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies (caused by an allergy to pollen, mold, dust, or pets). Prescription azelastine nasal spray… Read the full Azelastine Nasal Spray drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Clomipramine Donepezil Hydroxychloroquine Pitolisant
7 Major 1 Moderate
All (8) Major (7) Moderate (1)

Moderate

Azelastine Nasal Spray Cimetidine Tagamet An increased risk of azelastine adverse effects (increased somnolence, headache, bitter taste) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.