Azelastine Nasal Spray

Name: Azelastine Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions 97 cited references

Also sold as: Astelin® Nasal Spray Astepro Astepro Allergy® Nasal Spray Dymista® Nasal Spray (as a combination product containing Fluticasone, Azelastine)

About Azelastine Nasal Spray

Prescription and nonprescription (over the counter) azelastine nasal spray is used to relieve symptoms of rhinitis such as sneezing and a runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies (caused by an allergy to pollen, mold, dust, or pets). Prescription azelastine nasal spray… Read the full Azelastine Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Clomipramine Donepezil Hydroxychloroquine Pitolisant

7 Major 1 Moderate

All (8) Major (7) Moderate (1)

Major

Azelastine Nasal Spray Amifampridine Increased risk of seizures Details Azelastine Nasal Spray Bupropion Aplenzin Increased risk of seizures Details Azelastine Nasal Spray Clomipramine Anafranil Increased risk of seizures Details Azelastine Nasal Spray Donepezil Adlarity Reduced seizure threshold Details Azelastine Nasal Spray Hydroxychloroquine Plaquenil An increased risk of seizures Details Azelastine Nasal Spray Pitolisant Wakix Reduced efficacy of pitolisant Details Azelastine Nasal Spray Tramadol ConZip An increased risk of seizure Details

Moderate

Azelastine Nasal Spray Cimetidine Tagamet An increased risk of azelastine adverse effects (increased somnolence, headache, bitter taste) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.