Azilsartan Medoxomil

38 interactions 1 explained in plain English
Also sold as: Edarbi
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Azilsartan Medoxomil Lisinopril Prinivil Explained Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Benazepril Lotensin Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Captopril Capoten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Cyclosporine Injection Atopica An increased risk of hyperkalemia Details Azilsartan Medoxomil Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia Details Azilsartan Medoxomil Digoxin Cardoxin® An increased digoxin exposure Details Azilsartan Medoxomil Enalapril Epaned Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Fosinopril Monopril® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Furosemide Injection Disal Severe hypotension and deterioration in renal function, including renal failure Details Azilsartan Medoxomil Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Azilsartan Medoxomil Moexipril Univasc® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Azilsartan Medoxomil Perindopril Aceon Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details

Moderate

Azilsartan Medoxomil Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Azilsartan Medoxomil Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Diclofenac Transdermal Patch Flector Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Etodolac Lodine Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Fenoprofen Fenopron Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Flurbiprofen Ansaid Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Ibuprofen Addaprin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Azilsartan Medoxomil Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Azilsartan Medoxomil Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Azilsartan Medoxomil Ketoprofen Actron® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Ketorolac Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Ketorolac Injection Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Ketorolac Nasal Spray Sprix Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Ketorolac Ophthalmic Acular Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Meclofenamate Meclodium® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Mefenamic Acid Ponstel® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Meloxicam Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Meloxicam Injection Alloxate Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Nabumetone Relafen Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Azilsartan Medoxomil Naproxen Aleve Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.