Balsalazide

23 interactions
Also sold as: Colazal Colazal® Giazo®
About Balsalazide

Balsalazide is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults and children 5 years of age and older. Balsalazide is an anti-inflammatory drug. It is converted in the body to mesalamine and works by reducing bowel inflammat… Read the full Balsalazide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Bromfenac Ophthalmic Etodolac Mercaptopurine Naproxen Mesalamine
19 Major 4 Moderate
All (23) Major (19) Moderate (4)

Major

Balsalazide Azathioprine Azasan An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Balsalazide Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Balsalazide Etodolac Lodine Increased risk of bleeding Details Balsalazide Fenoprofen Fenopron Increased risk of bleeding Details Balsalazide Flurbiprofen Ansaid Increased risk of bleeding Details Balsalazide Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Balsalazide Ibuprofen Addaprin Increased risk of bleeding Details Balsalazide Ketoprofen Actron® Increased risk of bleeding Details Balsalazide Meclofenamate Meclodium® Increased risk of bleeding Details Balsalazide Mefenamic Acid Ponstel® Increased risk of bleeding Details Balsalazide Meloxicam Alloxate Increased risk of bleeding Details Balsalazide Meloxicam Injection Alloxate Increased risk of bleeding Details Balsalazide Mercaptopurine Purinethol® An increased risk of myelosuppression and an increased risk of hepatotoxicity Details Balsalazide Mesalamine Apriso Increased risk of bleeding Details Balsalazide Mesalamine Rectal Canasa Increased risk of bleeding Details Balsalazide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Balsalazide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Balsalazide Nabumetone Relafen Increased risk of bleeding Details Balsalazide Naproxen Aleve Increased risk of bleeding Details

Moderate

Balsalazide Furosemide Injection Disal An increased risk of salicylate toxicity Details Balsalazide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Balsalazide Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Balsalazide Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.