Bempedoic Acid

Name: Bempedoic Acid Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

11 interactions 19 cited references

Also sold as: Nexletol Nexletol®

About Bempedoic Acid

Bempedoic acid is a cholesterol-lowering medication used to reduce "bad" cholesterol in adults with inherited high cholesterol or heart disease. Read the full Bempedoic Acid drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Simvastatin Atogepant Atrasentan Pravastatin

4 Major 7 Moderate

All (11) Major (4) Moderate (7)

Major

Bempedoic Acid Simvastatin Flolipid Increased simvastatin exposure and an increased risk of myopathy Details Bempedoic Acid Atogepant Qulipta Increased atogepant exposure Details Bempedoic Acid Atrasentan Increased atrasentan exposure and an increased risk of atrasentan-related adverse reactions Details Bempedoic Acid Pravastatin Pravachol Increased pravastatin exposure and an increased risk of myopathy Details

Moderate

Bempedoic Acid Bezafibrate An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Ciprofibrate An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Clofibrate An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Fenofibrate Antara An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Fenofibric Acid Fibricor An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Gemfibrozil Lopid An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Bempedoic Acid Seladelpar Increased seladelpar exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.