Benperidol

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Morphine Injection Cabergoline Butorphanol Injection Butorphanol Nasal Spray Nalbuphine Injection
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Benperidol Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Benperidol Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Benperidol Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Benperidol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Benperidol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Benperidol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Benperidol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Benperidol Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Benperidol Diazepam Rectal Diastat Increased risk of CNS depression Details Benperidol Esketamine Nasal Spray Spravato Increased risk of sedation Details Benperidol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Benperidol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Benperidol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Benperidol Hydroxychloroquine Plaquenil An increased risk of seizures Details Benperidol Lacosamide Injection Motpoly An increased risk of CNS depression Details Benperidol Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Benperidol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Benperidol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Benperidol Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Benperidol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Benperidol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.