Benzhydrocodone

56 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Benzhydrocodone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Benzhydrocodone Abametapir Explained Increased exposure of CYP3A4 substrate Details Benzhydrocodone Amitriptyline Elavil Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of serotonin syndr... Details Benzhydrocodone Sertraline Explained An increased risk of serotonin syndrome Details Benzhydrocodone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Benzhydrocodone Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Benzhydrocodone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Benzhydrocodone Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Benzhydrocodone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Benzhydrocodone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Benzhydrocodone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Benzhydrocodone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Benzhydrocodone Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Cyclosporine Injection Atopica Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Benzhydrocodone Cyclosporine Ophthalmic Cequa Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Benzhydrocodone Dexamethasone Injection Decadron Reduced HYDROcodone exposure and reduced efficacy HYDROcodone Details Benzhydrocodone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced HYDROcodone exposure and reduced efficacy HYDROcodone Details Benzhydrocodone Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Benzhydrocodone Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Benzhydrocodone Diphenhydramine Injection Banophen Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of respiratory dep... Details Benzhydrocodone Diphenhydramine Topical Afterbite with Antihistamine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of respiratory dep... Details Benzhydrocodone Dolasetron Anzemet An increased risk of serotonin syndrome Details Benzhydrocodone Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Benzhydrocodone Esketamine Nasal Spray Spravato Increased risk of sedation Details Benzhydrocodone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Benzhydrocodone Furosemide Injection Disal Reduced efficacy of diuretics Details Benzhydrocodone Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Benzhydrocodone Granisetron Injection Granisol An increased risk of serotonin syndrome Details Benzhydrocodone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Benzhydrocodone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Benzhydrocodone Hydroxychloroquine Plaquenil An increased risk of seizures Details Benzhydrocodone Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Benzhydrocodone Ketoconazole Topical Extina® Foam Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Benzhydrocodone Lacosamide Injection Motpoly An increased risk of CNS depression Details Benzhydrocodone Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.