Berberine

Name: Berberine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Finerenone Loperamide Methylergonovine Nifedipine

4 Major 3 Moderate

All (7) Major (4) Moderate (3)

Major

Berberine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Berberine Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Berberine Methylergonovine Methergine Increased methylergonovine exposure Details Berberine Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Berberine Dofetilide Tikosyn Increased dofetilide exposure Details Berberine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Berberine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.