Betaxolol and Iohexol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Betaxolol
Iohexol
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Lower threshold for contrast reactions, increased risk of more severe contrast reaction, reduced efficacy when treating hypersensitivity reaction
Interaction Deep Dive
Concomitant use of iohexol and a beta-adrenergic blocking agent must be used cautiously due to an increased risk and severity of hypersensitivity reactions. Beta blockers lower the threshold for reactions and increase the severity of contrast reactions. Additionally, beta blockers reduce the responsiveness of epinephrine for the treatment of hypersensitivity reactions1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Betaxolol and Iohexol together?
Lower threshold for contrast reactions, increased risk of more severe contrast reaction, reduced efficacy when treating hypersensitivity reaction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Betaxolol and Iohexol interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Betaxolol or Iohexol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: OMNIPAQUE intravenous injection, iohexol intravenous injection. GE Healthcare Inc (per FDA), Marlborough, MA, 2017. DailyMed
Keep reading about Betaxolol
Keep reading about Iohexol
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