Bismuth Subsalicylate

24 interactions
Also sold as: Bismarex Bismusal Bismusal® Estomaquil Kaopectate Reformulated Aug 2006 Kaopectate® Peptic Relief® Pepto-bismol Pepto-Bismol® Percy Medicine Pink Bismuth® Stomach Relief®
About Bismuth Subsalicylate

An antidiarrheal medication used to treat diarrhea, heartburn, and upset stomach. Read the full Bismuth Subsalicylate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bromfenac Ophthalmic Etodolac Mesalamine Rectal Mesalamine Naproxen Ibuprofen
15 Major 9 Moderate
All (24) Major (15) Moderate (9)

Major

Bismuth Subsalicylate Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Bismuth Subsalicylate Etodolac Lodine Increased risk of bleeding Details Bismuth Subsalicylate Fenoprofen Fenopron Increased risk of bleeding Details Bismuth Subsalicylate Flurbiprofen Ansaid Increased risk of bleeding Details Bismuth Subsalicylate Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Bismuth Subsalicylate Ibuprofen Addaprin Increased risk of bleeding Details Bismuth Subsalicylate Ketoprofen Actron® Increased risk of bleeding Details Bismuth Subsalicylate Meclofenamate Meclodium® Increased risk of bleeding Details Bismuth Subsalicylate Mefenamic Acid Ponstel® Increased risk of bleeding Details Bismuth Subsalicylate Meloxicam Alloxate Increased risk of bleeding Details Bismuth Subsalicylate Meloxicam Injection Alloxate Increased risk of bleeding Details Bismuth Subsalicylate Mesalamine Apriso Increased risk of bleeding Details Bismuth Subsalicylate Mesalamine Rectal Canasa Increased risk of bleeding Details Bismuth Subsalicylate Nabumetone Relafen Increased risk of bleeding Details Bismuth Subsalicylate Naproxen Aleve Increased risk of bleeding Details

Moderate

Bismuth Subsalicylate Demeclocycline Declomycin® Decreased demeclocycline effectiveness Details Bismuth Subsalicylate Doxycycline Injection Acticlate Reduced doxycycline efficacy Details Bismuth Subsalicylate Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Bismuth Subsalicylate Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Bismuth Subsalicylate Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Bismuth Subsalicylate Minocycline Amzeeq Decreased minocycline effectiveness Details Bismuth Subsalicylate Minocycline Topical Amzeeq Decreased minocycline effectiveness Details Bismuth Subsalicylate Omadacycline Nuzyra Decreased effectiveness of omadacycline Details Bismuth Subsalicylate Omadacycline Injection Nuzyra Decreased effectiveness of omadacycline Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.