Bretylium

23 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Arsenic Trioxide Ofloxacin Otic Octreotide Ofloxacin Dofetilide

23 Major

All (23) Major (23)

Major

Bretylium Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Arsenic Trioxide Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Arsenic Trioxide Injection Trisenox Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Bretylium Chloroquine Aralen® Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Bretylium Dofetilide Tikosyn An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Bretylium Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Bretylium Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Bretylium Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Ketoconazole Topical Extina® Foam An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Bretylium Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Bretylium Levofloxacin Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Levofloxacin Injection Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Ofloxacin Floxin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Bretylium Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.