Bromfenac Ophthalmic

253 interactions 197 cited references

Also sold as: Bromday® Bromsite Bromsite® Prolensa Prolensa® Xibrom®

About Bromfenac Ophthalmic

Bromfenac ophthalmic is used to treat eye swelling and redness (inflammation) and pain that can occur after cataract surgery. Bromfenac ophthalmic is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of certain natural substances that cause pain and swellin… Read the full Bromfenac Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Phenylbutazone Phenprocoumon Phenindione Pentoxifylline

1 Contraindicated 197 Major 55 Moderate

All (253) Contraindicated (1) Major (197) Moderate (55)

Contraindicated

Bromfenac Ophthalmic Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Bromfenac Ophthalmic Abciximab An increased risk of bleeding Details Bromfenac Ophthalmic Aceclofenac Increased risk of bleeding Details Bromfenac Ophthalmic Acemetacin Increased risk of bleeding Details Bromfenac Ophthalmic Acenocoumarol An increased risk of bleeding Details Bromfenac Ophthalmic Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Bromfenac Ophthalmic Amineptine An increased risk of bleeding Details Bromfenac Ophthalmic Amitriptyline Elavil An increased risk of bleeding Details Bromfenac Ophthalmic Amitriptylinoxide An increased risk of bleeding Details Bromfenac Ophthalmic Amoxapine An increased risk of bleeding Details Bromfenac Ophthalmic Amtolmetin Guacil Increased risk of bleeding Details Bromfenac Ophthalmic Anagrelide Agrylin An increased risk of bleeding Details Bromfenac Ophthalmic Apixaban Eliquis An increased risk of bleeding Details Bromfenac Ophthalmic Ardeparin An increased risk of bleeding Details Bromfenac Ophthalmic Argatroban An increased risk of bleeding Details Bromfenac Ophthalmic Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Bromfenac Ophthalmic Balsalazide Colazal Increased risk of bleeding Details Bromfenac Ophthalmic Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Bemiparin An increased risk of bleeding Details Bromfenac Ophthalmic Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Betrixaban Bevyxxa® An increased risk of bleeding Details Bromfenac Ophthalmic Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Bromfenac Ophthalmic Bivalirudin Angiomax An increased risk of bleeding Details Bromfenac Ophthalmic Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Bromfenac Ophthalmic Bufexamac Increased risk of bleeding Details Bromfenac Ophthalmic Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Cangrelor Kengreal An increased risk of bleeding Details Bromfenac Ophthalmic Celecoxib Celebrex Increased risk of bleeding Details Bromfenac Ophthalmic Certoparin An increased risk of bleeding Details Bromfenac Ophthalmic Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Bromfenac Ophthalmic Choline Salicylate Increased risk of bleeding Details Bromfenac Ophthalmic Cilostazol Pletal® An increased risk of bleeding Details Bromfenac Ophthalmic Citalopram Celexa An increased risk of bleeding Details Bromfenac Ophthalmic Clomipramine Anafranil An increased risk of bleeding Details Bromfenac Ophthalmic Clonixin Increased risk of bleeding Details Bromfenac Ophthalmic Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details Bromfenac Ophthalmic Clopidogrel Plavix An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.