Bromopride and Amitriptyline: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amitriptyline
Bromopride
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Bromopride (a medicine used for nausea and stomach problems) and amitriptyline (Elavil, used for depression, nerve pain, or sleep) can each affect the body in ways that lead to movement problems. These are called extrapyramidal reactions, and they can include muscle stiffness, restlessness, tremors, or unusual movements. When the two are taken together, those effects may add up, which is why using them together is generally advised against.
Please don't stop either medicine on your own. Talk with your pharmacist or doctor, they can review your list and choose a safer option or a different plan for you.
Interaction: Additive risk of extrapyramidal reactions (EPS) with concomitant bromopride and amitriptyline.
- Mechanism: Additive/pharmacodynamic. Bromopride is a dopamine (D2) antagonist that can cause EPS; amitriptyline contributes central effects that may worsen movement disturbances.
- Direction: Increased EPS risk (neither agent is dependent on the other for activation).
- Evidence: Theoretical; onset unspecified.
- Severity: Combination is classified as contraindicated.
- Management: Avoid concurrent use; select an alternative antiemetic or reassess therapy. If unavoidable, monitor closely for dystonia, akathisia, parkinsonism, and tremor.
What happens
Increased risk of extrapyramidal reactions
Interaction Deep Dive
The combined administration of bromopride with additional agents capable of inducing extrapyramidal reactions is contraindicated1.
Why it happens (mechanism)
Additive extrapyramidal side effects
How to manage this interaction
The safest approach here is usually to avoid using these two together, since the combination is flagged as contraindicated.
- Keep taking both exactly as prescribed until you speak with a professional, do not stop on your own.
- Let your pharmacist or prescriber know you have been prescribed both, they can choose an alternative anti-nausea medicine or adjust your therapy.
- Watch for and report new muscle stiffness, restlessness, tremor, or unusual movements right away.
Your care team can manage this by picking a safer combination for you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Bromopride and Amitriptyline together?
Combining bromopride and amitriptyline can add up to a higher risk of movement side effects and is considered contraindicated, so ask your pharmacist or doctor about a safer alternative before taking both. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Bromopride and Amitriptyline interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Bromopride and Amitriptyline interaction managed?
The safest approach here is usually to avoid using these two together, since the combination is flagged as contraindicated. Keep taking both exactly as prescribed until you speak with a professional, do not stop on your own. Let your pharmacist or prescriber know you have been prescribed both, they can choose an alternative anti-nausea medicine or adjust your therapy. Watch for and report new musc… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Bromopride or Amitriptyline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: DIGESAN(R) oral capsules, bromopride oral capsules. Sanofi-Aventis Farmaceutica Ltda (per Anvisa), Suzano, Brazil, 2014.
Keep reading about Amitriptyline
Keep reading about Bromopride
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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