Bupivacaine

Name: Bupivacaine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions 1 explained in plain English

Also sold as: Exparel Marcaine Nocita Posimir Sensorcaine Xaracoll

Read the full Bupivacaine drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Chloroprocaine Hydroxychloroquine

2 Major 7 Moderate

All (9) Major (2) Moderate (7)

Major

Bupivacaine Chloroprocaine Increased risk of toxicity Details Bupivacaine Hydroxychloroquine Plaquenil An increased risk of seizures Details

Moderate

Bupivacaine Lisinopril Prinivil Explained Bradycardia and hypotension with loss of consciousness Details Bupivacaine Benazepril Lotensin Bradycardia and hypotension with loss of consciousness Details Bupivacaine Captopril Capoten® Bradycardia and hypotension with loss of consciousness Details Bupivacaine Enalapril Epaned Bradycardia and hypotension with loss of consciousness Details Bupivacaine Fosinopril Monopril® Bradycardia and hypotension with loss of consciousness Details Bupivacaine Moexipril Univasc® Bradycardia and hypotension with loss of consciousness Details Bupivacaine Perindopril Aceon Bradycardia and hypotension with loss of consciousness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.