Buprenorphine

633 interactions 533 explained in plain English 652 cited references
Also sold as: Belbuca Brixadi Buprenex BuTrans Simbadol Sublocade Zorbium
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Buprenorphine Fentanyl Transdermal Patch Duragesic® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Buprenorphine Furosemide Injection Disal Reduced efficacy of diuretics Details Buprenorphine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Buprenorphine Glycopyrronium Topical Cuvposa® An increased risk of paralytic ileus Details Buprenorphine Goserelin Implant Zoladex An increased risk of QT interval prolongation Details Buprenorphine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Buprenorphine Granisetron Injection Granisol An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Buprenorphine Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Buprenorphine Hydromorphone Injection Dilaudid Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Buprenorphine Hydromorphone Rectal available generically Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Buprenorphine Inotuzumab Ozogamicin Injection Besponsa An increased risk of QT interval prolongation Details Buprenorphine Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of paralytic ileus Details Buprenorphine Ipratropium Oral Inhalation Atrovent® HFA An increased risk of paralytic ileus Details Buprenorphine Lacosamide Injection Motpoly An increased risk of CNS depression Details Buprenorphine Lenacapavir Injection Sunlenca Increased or reduced buprenorphine exposure Details Buprenorphine Lenacapavir Oral Sunlenca Increased or reduced buprenorphine exposure Details Buprenorphine Letermovir Injection Prevymis Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Buprenorphine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Buprenorphine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Buprenorphine Linezolid Injection Zyvox An increased risk of serotonin syndrome or opioid-related toxicity Details Buprenorphine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Buprenorphine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Buprenorphine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Buprenorphine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Buprenorphine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Buprenorphine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Buprenorphine Midazolam Nasal Spray Nayzilam An increased risk of CNS depression and respiratory depression Details Buprenorphine Midazolam Injection Nayzilam An increased risk of CNS depression and respiratory depression Details Buprenorphine Morphine Injection Astramorph® PF Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Buprenorphine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Buprenorphine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Buprenorphine Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Buprenorphine Nafcillin Injection Unipen® Injection Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Buprenorphine Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome and respiratory depr... Details Buprenorphine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Buprenorphine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Buprenorphine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Buprenorphine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Buprenorphine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.