Drug Interaction Report

Buprenorphine and Linezolid Injection: Interaction Details

A pharmacist-reviewed analysis of the Buprenorphine and Linezolid Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Buprenorphine

Belbuca Brixadi Buprenex BuTrans Simbadol Sublocade Zorbium
+

Linezolid Injection

Zyvox Zyvox®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 633 documented Buprenorphine interactions, 601 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of serotonin syndrome or opioid-related toxicity

Interaction Deep Dive

Concomitant administration of buprenorphine and an MAOI is not recommended, and a minimum of 14 days should elapse after discontinuing an MAOI before initiating therapy with buprenorphine. Concurrent administration or overlapping therapy with buprenorphine and an MAOI may result in CNS toxicity or serotonin syndrome, a hyper-serotonergic state characterized by symptoms such as agitation, changes in mental status, tachycardia, hyperthermia, hyperreflexia, nausea, vomiting, and diarrhea453.

Why it happens (mechanism)

Additive serotonergic effects

Common questions

Can I take Buprenorphine and Linezolid Injection together?

An increased risk of serotonin syndrome or opioid-related toxicity Always confirm with your pharmacist or prescriber before making any change.

How serious is the Buprenorphine and Linezolid Injection interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Buprenorphine or Linezolid Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (5)

  1. Product Information: BUTRANS(R) transdermal system patch, buprenorphine transdermal system patch. Purdue Pharma L.P. (per FDA), Stamford, CT, 2016. DailyMed
  2. Product Information: SUBOXONE(R) sublingual film, buprenorphine naloxone sublingual film. Indivior Inc (per FDA), Richmond, VA, 2017. DailyMed
  3. Product Information: BRIXADI(TM) subcutaneous extended-release injection, buprenorphine subcutaneous extended-release injection. Braeburn Inc (per FDA), Plymouth Meeting, PA, 2023. DailyMed
  4. Product Information: NUCYNTA(R) ER oral extended-release tablets, tapentadol oral extended-release tablets. Depomed, Inc (per FDA), Newark, CA, 2016. DailyMed
  5. Product Information: NUCYNTA(R) oral tablets, tapentadol oral tablets. Depomed Inc (per FDA), Newark, CA, 2016. DailyMed
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Buprenorphine

Keep reading about Buprenorphine

All Buprenorphine interactions (633)
Also serious with: Dronedarone Piperaquine Pimozide Phenelzine
Linezolid Injection

Keep reading about Linezolid Injection

All Linezolid Injection interactions (212) Linezolid Injection drug information
Also serious with: Tramadol Tranylcypromine Trazodone Trimipramine
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Buprenorphine + 1,4-butanediol Activated Charcoal Beer Gamma-hydroxybutyrate (ghb) Grapefruit Kava L-tryptophan Lithium + 206 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.