Linezolid Injection and Tramadol: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Tramadol
Linezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of serotonin syndrome or opioid toxicity
Interaction Deep Dive
Coadministration of traMADol and MAOIs, or traMADol administration within 14 days of receiving an MAOI, is contraindicated due to increased risk of unpredictable, severe, and sometimes fatal reactions in addition to increased risk of serotonin syndrome and opioid toxicity12. In addition, concomitant use of traMADol may also increase the risk of seizures in patients taking MAOI 1.
Why it happens (mechanism)
Additive serotonergic effects
Common questions
Can I take Linezolid Injection and Tramadol together?
Increased risk of serotonin syndrome or opioid toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Linezolid Injection and Tramadol interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Linezolid Injection or Tramadol need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Tramadol hydrochloride oral tablets, tramadol hydrochloride oral tablets. Strides Pharma, Inc (per DailyMed), East Brunswick, NJ, 2025. DailyMed
- Product Information: CONZIP(R) oral extended-release capsules, tramadol HCl oral extended-release capsules. Vertical Pharmaceuticals LLC (per FDA), Alpharetta, GA, 2023. DailyMed
Keep reading about Tramadol
Keep reading about Linezolid Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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