Linezolid Injection

212 interactions 484 cited references
Also sold as: Zyvox Zyvox®
About Linezolid Injection

Linezolid injection is used to treat infections, including pneumonia, and infections of the skin. Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth of bacteria. Antibiotics such as linezolid injection will not kill viruses that can cause colds, flu, or other infections. Us… Read the full Linezolid Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Linezolid Injection Amoxapine An increased risk of serotonin syndrome Details Linezolid Injection Amphetamine Dexedrine An increased risk of serotonin syndrome and an increased risk of amphetamine-related adverse reactions, like headaches and other s... Details Linezolid Injection Apraclonidine Potentiation of monoamine oxidase inhibitor effects Details Linezolid Injection Atomoxetine Atoncy An increased risk of atomoxetine-related serious or fatal adverse reactions (including hyperthermia, rigidity, myoclonus, autonomi... Details Linezolid Injection Benzphetamine An increased risk of hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Injection Brimonidine Alphagan Increased risk of brimonidine-related systemic side effects Details Linezolid Injection Bupropion Aplenzin Increased risk of hypertensive reactions Details Linezolid Injection Buspirone Bucapsol An increased risk of serotonin syndrome Details Linezolid Injection Carbamazepine Carbatrol An increased risk of serotonin syndrome Details Linezolid Injection Carbidopa Lodosyn Hypertensive crisis Details Linezolid Injection Carbinoxamine Carbzah Prolonged and intensified anticholinergic effects and an increased risk of carbinoxamine-related adverse reactions Details Linezolid Injection Citalopram Celexa An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Clomipramine Anafranil An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Clovoxamine CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of serotonin syndrome Details Linezolid Injection Cyclobenzaprine Amrix Increased risk of serotonin syndrome and an increased risk of hyperpyretic crisis seizures Details Linezolid Injection Cyproheptadine Prolonged and intensified anticholinergic effects and an increased cyproheptadine effects Details Linezolid Injection Desipramine Norpramin An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Desvenlafaxine Pristiq Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Injection Dexmethylphenidate Focalin Increased risk of hypertensive crisis (palpitations, headache, flushing, and sweating) Details Linezolid Injection Dextroamphetamine Dexedrine An increased risk of hypertensive crisis and an increased risk of serotonin syndrome Details Linezolid Injection Dextromethorphan Delsym An increased risk of serotonin syndrome Details Linezolid Injection Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Injection Dihydrocodeine Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Injection Dobutamine Increased hypertensive effects Details Linezolid Injection Dopamine Increased hypertensive effects Details Linezolid Injection Doxepin Prudoxin An increased risk of serotonin syndrome Details Linezolid Injection Doxylamine Aldex AN Prolonged and intensified anticholinergic effects (eg, severe dry mouth, constipation, decreased urination or sweating) Details Linezolid Injection Duloxetine An increased risk of CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Linezolid Injection Epinephrine Increased hypertensive effects Details Linezolid Injection Escitalopram Lexapro An increased risk of serotonin syndrome Details Linezolid Injection Femoxetine CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Fenfluramine Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Flesinoxan CNS toxicity or serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Fluoxetine RECONCILE An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Fluvoxamine An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Injection Gepirone Exxua An increased risk of serotonin syndrome and hypertensive crisis Details Linezolid Injection Guanadrel Decreased antihypertensive response to guanadrel or hypertensive crisis when guanadrel is initiated in a patient already receiving... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.