Linezolid Injection and Vilazodone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Vilazodone
Linezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status change)
Interaction Deep Dive
Concurrent use of vilazodone and an MAOI is contraindicated due to the potential for serotonin syndrome. Wait at least 14 days after discontinuing an MAOI before initiating vilazodone. Wait at least 14 days after discontinuing vilazodone before initiating therapy with an MAOI. If urgent treatment with linezolid is necessary in a patient receiving vilazodone and alternatives are not available, promptly discontinue vilazodone before initiating treatment with linezolid. Monitor all patients taking vilazodone for the emergence of serotonin syndrome. Discontinue treatment with vilazodone and any concomitant serotonergic agents immediately if the above symptoms occur, and initiate supportive symptomatic treatment. If concomitant use of vilazodone with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms1.
Why it happens (mechanism)
Additive serotonergic effects
Literature reports
1 report — tap to read
a) In clinical trials, a patient receiving safinamide developed serotonin syndrome with the concomitant use of an SSRI 2.
Common questions
Can I take Linezolid Injection and Vilazodone together?
An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status change) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Linezolid Injection and Vilazodone interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Linezolid Injection or Vilazodone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
Keep reading about Vilazodone
Keep reading about Linezolid Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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